Table 1

Decision rules on the evidence-base for CRP testing in acute pediatric infections and neonatal sepsis
Infection Type Evidence-Based CRP testing Non-Evidence-Based CRP testing Highest available Level of Evidence
Fever without focus ___ Baseline &/or follow up testing in patients with fever without focus who are >28 days of age Level I (SR)
Pneumonia ___ Baseline &/or follow up testing in febrile children with respiratory symptoms and an admission diagnosis of bronchitis, bronchiolitis, asthma, or pneumonia Level I (SR)
Urinary tract infections (UTI) Baseline &/or follow up testing in febrile pyelonephritis Baseline testing in febrile infants suspected to have UTI Level III & IV (Cross-sectional & retrospective studies)
Acute gastroenteritis ___ Baseline &/or follow up testing in febrile or non-febrile acute gastroenteritis No evidence
Meningitis ___ 1. Baseline testing in febrile children suspected to have meningitis Level IV (Retrospective studies)
2. Follow up testing in febrile children with meningitis
Acute osteomyelitis/Septic arthritis Baseline &/or follow up testing in acute osteomyelitis &/or septic arthritis ___ Level IV (Case series)
Acute appendicitis Baseline &/or follow up testing in acute appendicitis ___ Level IV (Cross-sectional studies)
Acute otitis media ___ Baseline &/or follow up testing in acute otitis media Level II (Cross-sectional studies)
Cellulitis ___ Any baseline or follow up testing in patients with any of those infections No evidence
Acute sinusitis
Tonsillitis
Neonatal sepsis Testing on three consecutive days of a suspected sepsis episode A single determination of CRP Level I (SR)

Nabulsi et al.

Nabulsi et al. BMC Pediatrics 2012 12:140   doi:10.1186/1471-2431-12-140

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