Table 2 |
|||||||
Growth outcomes and human milk fortification for all subjects and by human milk intake | |||||||
Group by proportion of enteral intake as human milk | p value | ||||||
All Subjects | <25% | 25-50% | 50-75% | >75% | All groups | >75% vs. <75% | |
Discharge weight, g, median (IQR) | 2782 (2460, 3215) | 3005 (2470, 3260) | 2765 (2500, 3690) | 2980 (2695, 3280) | 2685 (2335, 3035) | 0.008* | 0.0006 |
Discharge weight z- score, median (IQR) | −0.94 (−1.43, -0.19) | −0.72 (−1.43, -0.19) | −0.69 (−1.36, -0.05) | −0.95 (−1.28, 0.12) | −1.07 (−1.52, -0.29) | 0.36* | 0.09 |
SGA at discharge n (%) | 58 (34) | 7 (41) | 8 (27) | 9 (25) | 34 (39) | 0.36* | 0.18 |
Protein fortification, highest level | |||||||
n (%) | |||||||
2.0-2.3 g/dl | 34 (20) | 6 (35) | 8 (27) | 6 (17) | 14 (16) | 0.04† | 0.18 |
2.4-2.65 g/dl | 84 (49) | 6 (35) | 14 (46) | 16 (44) | 48 (55) | ||
2.5-2.7 g/dl | 53 (31) | 5 (29) | 8 (27) | 14 (39) | 26 (30) | ||
Change in weight z-score, birth to discharge, median (IQR) | −0.51‡ (−0.89, -0.03) | −0.1 (−0.61, 0.16) | −0.30 (−0.85, 0) | −0.32 (−0.73, 0.15) | −0.60 (−0.99, -0.15) | 0.17* | 0.03 |
*ANOVA or Chi square across all groups.
†Chi square across all fortification levels and all human milk intake groups.
‡ p < 0.0001 – t-test of change in weight z score = 0, infants experienced significant negative change in weight z-score from birth to discharge.
Colaizy et al.
Colaizy et al. BMC Pediatrics 2012 12:124 doi:10.1186/1471-2431-12-124