Table 2

Growth outcomes and human milk fortification for all subjects and by human milk intake
Group by proportion of enteral intake as human milk pvalue
All Subjects <25% 25-50% 50-75% >75% All groups >75% vs. <75%
Discharge weight, g, median (IQR) 2782 (2460, 3215) 3005 (2470, 3260) 2765 (2500, 3690) 2980 (2695, 3280) 2685 (2335, 3035) 0.008* 0.0006
Discharge weight z- score, median (IQR) −0.94 (−1.43, -0.19) −0.72 (−1.43, -0.19) −0.69 (−1.36, -0.05) −0.95 (−1.28, 0.12) −1.07 (−1.52, -0.29) 0.36* 0.09
SGA at discharge n (%) 58 (34) 7 (41) 8 (27) 9 (25) 34 (39) 0.36* 0.18
Protein fortification, highest level
n (%)
2.0-2.3 g/dl 34 (20) 6 (35) 8 (27) 6 (17) 14 (16) 0.04 0.18
2.4-2.65 g/dl 84 (49) 6 (35) 14 (46) 16 (44) 48 (55)
2.5-2.7 g/dl 53 (31) 5 (29) 8 (27) 14 (39) 26 (30)
Change in weight z-score, birth to discharge, median (IQR) −0.51‡ (−0.89, -0.03) −0.1 (−0.61, 0.16) −0.30 (−0.85, 0) −0.32 (−0.73, 0.15) −0.60 (−0.99, -0.15) 0.17* 0.03

*ANOVA or Chi square across all groups.

Chi square across all fortification levels and all human milk intake groups.

‡ p < 0.0001 – t-test of change in weight z score = 0, infants experienced significant negative change in weight z-score from birth to discharge.

Colaizy et al.

Colaizy et al. BMC Pediatrics 2012 12:124   doi:10.1186/1471-2431-12-124

Open Data