Table 8

Grouping of treatments for the clinical seizures group.

Antiepileptic Drugs (Cluster 1)


AED Subcluster 1

AED Subcluster 2

AED Subcluster 3


Valproic acid

Lamotrigine

Levetiracetam

Ethosuximide

Phenytoin

Clonazepam

Carbamazepine

Oxcarbazepine

Topiramate

Gabapentin

Zonisamide

Felbamate

Phenobarbitol


Non-Antiepileptic Drugs (Cluster 2)


Non-AED Subcluster 1

Non-AED Subcluster 2

Non-AED Subcluster 3


Ketogenic Diet

Atkins Diet

Gluten-free Casein-free Diet

Hyperbaric Oxygen Therapy

Vitamin B6

Intravenous Immunoglobulin

L-Carnitine/Acetyl-L-Carnitine

CoQ10

Vitamin B12

Dimethylglycine

Taurine

GABA

Magnesium

5HTP

L-Carnosine

Chelation

Glutathione

Specific carbohydrate diet

Steroids

Vagus Nerve Stimulator


Two levels of cluster analyses were performed. The first cluster analysis (Tier 1) divided treatments into anti-epileptic medication and non-antiepileptic medications. Cluster analysis was applied to the two Tier 1 clusters separated. Three Tier 2 subclusters were found for both initial clusters.

Frye et al. BMC Pediatrics 2011 11:37   doi:10.1186/1471-2431-11-37

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