Table 11

Rates of specific adverse effects for the antiepileptic drug treatments reported to be most effective

Adverse Effects

Valproic Acid

Lamotrigine

Levetiracetam

Ethosuximide


Mood Instability or Anger

10%

10%

21%

4%


Behavioral Change

5%

3%

8%

0%


Drowsiness/tiredness/fatigue

10%

4%

8%

7%


Change in appetite or weight

11%

2%

3%

7%


Increase in seizures

2%

5%

4%

7%


Constipation or diarrhea

3%

2%

1%

0%


Sleep disruption

4%

5%

3%

4%


Inattention or confusion

4%

3%

4%

0%


Rash or allergic reaction

1%

7%

1%

0%


Hyperactivity

4%

3%

3%

4%


Nausea and/or vomiting

2%

3%

1%

4%


Ataxia, tremor or dizziness

6%

3%

1%

0%


Unusual infection

1%

0%

1%

0%


Movement disorder

1%

2%

2%

0%


Anxiety

1%

1%

2%

0%


Headache

1%

3%

0%

0%


Hair loss

3%

1%

0%

0%


Visual disturbances

0%

1%

1%

0%


Speech disturbance

3%

4%

4%

0%


Enuresis

1%

0%

1%

0%


Other

6%

0%

2%

4%


Frye et al. BMC Pediatrics 2011 11:37   doi:10.1186/1471-2431-11-37

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