Table 8

Primary Amino Acids.

Amino Acids

Neuro-typicals

(n = 44)

Arizona Treatment Group

(n = 18)

Arizona Placebo Group

(n = 20)


Pre

Post

% change

p-value

Pre

Post

% change

p-value


Histidine

8.2

+/- 1.3

8.7

+/- 2.5

9.6

+/- 1.3

+10%

n.s.

8.8

+/0 1.5

8.0

+/- 1.9

-9%

n.s.


Isoleucine

5.8

+/- 1.6

5.3

+/- 1.3

5.7

+/- 1.3

+8%

n.s.

5.2

+/- 0.8

6.0

+/- 1.5

16%

0.03


Leucine

10.7

+/- 2.1

11.0

+/- 2.5

11.4

+/- 2.8

+4%

n.s.

10.5

+/- 2.0

10.4

+/- 1.8

-1%

n.s.


Lysine

14.5

+/- 4.8

12.6

+/- 3.8

14.8

+/- 4.1

+17%

0.10

14.2

+/- 3.5

14.9

+/- 2.8

+5%

n.s.


Methionine

1.75

+/- 0.34

1.84

+/- 0.57

2.02

+/- 0.48

+10%

n.s.

1.92

+/- 0.45

1.93

+/- 0.64

+1%

n.s.


Phenylalanine

4.83

+/- 0.83

4.61

+/- 0.55

4.68

+/- 1.0

+2%

n.s.

4.36

+/- 0.63

4.65

+/- 0.66

+7%

n.s.


Threonine

8.88

+/- 2.1

9.2

+/- 2.6

7.9

+/- 1.8

-14%

0.07

9.4

+/- 3.6

8.7

+/- 2.4

-7%

n.s.


Tryptophan

4.33

+/- 1.0

3.32

+/- 0.9

4.11

+/- 1.7

+24%

0.06

3.47

+/- 1.1

4.17

+/- 1.3

+20%

0.04


Valine

20.5

+/- 4.3

20.6

+/- 4.3

20.0

+/- 4.2

-3%

n.s.

18.4

+/- 3.5

20.2

+/- 3.7

+10%

0.06



Alanine

33.4

+/- 8.9

36.6

+/- 9.0

37.4

+/- 12

+2%

n.s.

36.1

+/- 10

36.8

+/- 11

+2%

n.s.


Arginine

6.7

+/- 1.8

5.9

+/- 2.2

7.5

+/- 1.6

+26%

0.006

6.9

+/- 2.0

7.8

+/- 1.5

+14%

0.02


Asparagine

4.38

+/- 0.83

4.50

+/- 1.0

4.15

+/- 1.0

-8%

n.s.

4.26

+/- 1.42

3.92

+/- 0.84

-8%

n.s.


Aspartate

0.82

+/- 0.39

0.83

+/- 0.37

0.88

+/- 0.33

+6%

n.s.

0.69

+/- 0.21

0.82

+/- 0.37

+18%

n.s.


Cystine + cysteine

3.48

+/- 0.74

3.57

+/- 0.72

3.36

+/- 1.2

-6%

n.s.

3.01

+/- 0.81

3.40

+/- 0.87

+13%

n.s.


Glutamate

5.83

+/- 1.8

6.9

+/- 1.5

7.66

+/- 1.5

+12%

n.s.

6.4

+/- 1.5

6.6

+/- 1.5

+4%

n.s.


Glutamine

41.3

+/- 6.8

43.1

+/- 8.3

38.2

+/- 5.9

-11%

.08

42.4

+/- 11

38.4

+/- 5.0

-10%

0.10


Glycine

27.3

+/- 10

23.8

+/- 6.5

28.6

+/- 6.7

+20%

0.02

28.9

+/- 11

29.3

+/- 9.1

+1%

n.s.


Proline

15.8

+/- 4.9

15.9

+/- 4.2

16.0

+/- 4.9

+1%

n.s.

15.3

+/- 6.6

16.6

+/- 5.7

+8%

n.s.


Serine

9.5

+/- 2.1

9.9

+/- 2.1

8.9

+/- 1.5

-10%

0.01

10.6

+/- 2.1

9.7

+/- 1.8

-8%

0.01


Tyrosine

6.1

+/- 1.6

5.5

+/- 1.3

5.9

+/- 1.3

+6%

n.s.

5.6

+/- 1.1

6.0

+/- 1.3

+8%

n.s.


The average levels of primary amino acids in plasma (in units of micromoles per 100 ml) measured in the Neurotypical group and the Autism Treatment and Autism Placebo groups (pre and post) who completed the study are reported below, along with their standard deviations. The p-value for a t-test comparison of the change in the level is reported. If the p-value is below 0.05, then the result is highlighted.

Adams et al. BMC Pediatrics 2011 11:111   doi:10.1186/1471-2431-11-111

Open Data