Table 4 |
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|
Retention and outcomes for HIV-infected children in the first 6 months of antiretroviral therapy in Zambia, by year of enrollment |
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|
First Year N (%) |
Second Year N (%) |
Third Year N (%) |
Fourth Year N (%) |
p-trenda |
|
|
|
|||||
|
Urban |
n = 119 |
n = 133 |
n = 87 |
N = 97 |
|
|
|
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|
At ART initiation |
|||||
|
Age (yrs): Med (IQR) |
7.4 (3.6, 10.6) |
6.8 (3.0, 9.7) |
7.0 (3.7, 9.9) |
6.0 (2.4, 9.1) |
0.21 |
|
CD4%: Med (IQR) |
8.8 (4.8, 12.7) |
11.6 (6.8, 17.5) |
11.4 (7.1, 16.0) |
12.8 (9.0, 18.6) |
<0.0001 |
|
Missing |
11 (9.2) |
17 (12.8) |
4 (4.6) |
3 (3.1) |
|
|
At 6 months |
|||||
|
Still receiving care |
90 (75.6) |
104 (78.2) |
67 (77.0) |
86 (88.7) |
0.03 |
|
Death |
8 (6.7) |
12 (9.0) |
3 (3.5) |
0 (0.0) |
0.009 |
|
Transferred |
7 (5.9) |
7 (5.3) |
7 (5.1) |
4 (4.1) |
0.81 |
|
Defaulted |
14 (11.8) |
10 (7.5) |
10 (11.5) |
7 (7.2) |
0.44 |
|
Immunologic outcome |
N = 49 (54.4)b |
N = 67 (64.4) |
N = 47 (70.2) |
N = 33 (38.4) |
|
|
CD4%: Med (IQR) |
22.7 (15.9, 27.8) |
24.5 (19.7, 33.1) |
22.7 (16.0, 28.5) |
26.7 (22.4, 31.8) |
0.15 |
|
Change in CD4%: Med (IQR)c |
12.4 (8.1, 15.9) |
13.3 (9.1, 17.7) |
10.3 (4.2, 14.3) |
12.8 (6.7, 16.6) |
0.24 |
|
Clinical outcome |
N = 48 (53.3)b |
N = 74 (71.2) |
N = 49 (73.1) |
N = 35 (40.7) |
|
|
WAZ < -2 |
18 (37.5) |
32 (43.2) |
21 (42.9) |
11 (31.4) |
0.65 |
|
|
|||||
|
Rural |
n = 19 |
n = 39 |
n = 71 |
||
|
|
|||||
|
At ART initiation |
|||||
|
Age (yrs): Med (IQR) |
8.1 (3.4, 10.1) |
6.5 (1.9, 10.7) |
3.1 (1.7, 7.3) |
0.03 |
|
|
CD4%: Med (IQR) |
9.0 (9.0, 9.0) |
11.8 (8.0, 16.0) |
13.7 (9.5, 18.4) |
0.23 |
|
|
Missing |
18 (94.7) |
13 (33.3) |
27 (38.0) |
||
|
At 6 months |
|||||
|
Still receiving care |
16 (84.2) |
31 (79.5) |
51 (71.8) |
0.21 |
|
|
Death |
2 (10.5) |
5 (12.8) |
9 (12.7) |
0.84 |
|
|
Transferred |
1 (5.3) |
2 (5.1) |
3 (4.2) |
0.81 |
|
|
Defaulted |
0 (0.0) |
1 (2.6) |
8 (11.3) |
0.04 |
|
|
Immunologic outcome |
N = 4 (25.0)b |
N = 13 (41.9) |
N = 20 (39.2) |
||
|
CD4%: Med (IQR) |
12.1 (10.6, 28.8) |
19.4 (14.4, 33.1) |
25.9 (18.2, 32.9) |
0.22 |
|
|
Change in CD4%: Med (IQR)c |
3.4 (3.4, 3.4) |
7.7 (-2.4, 20.0) |
12.6 (4.9, 21.0) |
0.29 |
|
|
Clinical outcome |
N = 12 (75.0)b |
N = 18 (58.1) |
N = 32 (62.8) |
||
|
WAZ < -2 |
8 (66.7) |
10 (55.6) |
16 (50.0) |
0.33 |
|
|
|
|||||
|
ART: antiretroviral therapy; WAZ: Weight-for-age z-score (only for children younger than 10 years); IQR: interquartile range a p-trend calculated from Mantel-Haenszel χ2 for categorical variables and Cuzick's non-parametric test for trend for continuous variable. b Numbers in parentheses represent the proportion of those receiving care at 6 months for whom a measure is available c Samples sizes are smaller than indicated due to missing data at ART initiation |
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|
Sutcliffe et al. BMC Pediatrics 2010 10:54 doi:10.1186/1471-2431-10-54 |
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