Table 1

MAPPiNO Collaboration: citations for eligible trials as at October 2009

Trial identifier

Main citation


Ballard 2006

Ballard RA, Truog WE, Cnaan A, et al. Inhaled Nitric Oxide in preterm infants undergoing mechanical ventilation. New England Journal of Medicine 2006; 355(4):343-53.


Dani 2006

Dani C, Bertini G, Pezzati M, et al. Inhaled Nitric Oxide in very preterm infants with severe respiratory distress syndrome. Acta Pediatrica 2006; 95: 1116-1123.


Hascoet 2005

Hascoet JM, Fresson J, Claris O, et al. The safety and efficacy of Nitric Oxide therapy in premature infants. Journal of Pediatrics 2005; 146 (3):318-23.


INNOVO 2005

INNOVO. Neonatal ventilation with inhaled Nitric Oxide versus ventilatory support without inhaled Nitric Oxide for preterm infants with severe respiratory failure: the INNOVO multicentre randomized controlled trial. Pediatrics 2005; 115 (4):926-36.


Kinsella 1999

Kinsella JP. Inhaled Nitric Oxide in premature neonates with severe hypoxaemic respiratory failure: a randomised controlled trial. Lancet 1999; 354(9184):1061.


Kinsella 2006

Kinsella JP, Cutter GR, Walsh WF, et al. Early inhaled Nitric Oxide therapy in premature newborns with respiratory failure. New England Journal of Medicine 2006; 355(4):354-64.


Mercier 1999

Mercier JC, Thebaud B, Onody P. Early compared with delayed inhaled Nitric Oxide in moderately hypoxaemic neonates with respiratory failure: a randomised controlled trial. Lancet 1999; 354(9184):1066.


Schreiber 2003

Schreiber MD, Gin-Mestan K, Marks JD, et al. Inhaled Nitric Oxide in Premature Infants with the Respiratory Distress Syndrome. New England Journal of Medicine 2003; 349(22):2099-107.

Mestan KKL, Marks JD, Hecox K, et al. Neurodevelopmental Outcomes of Premature Infants Treated with Inhaled Nitric Oxide. New England Journal of Medicine 2005; 353(1):23-32.


Srisuparp 2002

Srisuparp P, Heitschmidt M, Schreiber MD. Inhaled Nitric Oxide therapy in premature infants with mild to moderate respiratory distress syndrome. J Med Assoc Thai 2002; 85(Suppl 2): S469-S478.


Su 2008

Su PH, Chen JY. Inhaled Nitric Oxide in the management of preterm infants with severe respiratory failure. Journal of Perinatology 2008; 28: 112-116.


Subhedar 1997

Subhedar NV, Ryan SW, Shaw NJ. Open randomised controlled trial of inhaled Nitric Oxide and early dexamethasone in high risk preterm infants. Arch Dis Child Fetal Neonatal Ed 1997; 77(3): F185-F190.

Subhedar NV, Shaw NJ. Changes in oxygenation and pulmonary haemodynamics in preterm infants treated with inhaled Nitric Oxide. Arch Dis Child Fetal Neonatal Ed 1997; 77(3):F191-F197.


Van Meurs 2005

Van Meurs KP, Wright LL, Ehrenkranz RA, et al. Inhaled Nitric Oxide for Premature Infants with Severe Respiratory Failure. New England Journal of Medicine 2005; 353(1):13-22.


EUNO 2008 (completed RCT awaiting publication)

JC Mercier, H. Hummler, X Durrmeyer, et al. The effects of inhaled Nitric Oxide on the development of bronchopulmonary dysplasia in preterm infants: the 'EUNO' multicentre randomised clinical trial. Abstract: European Academy of Pediatrics, Nice, France, October 25, 2008.


Askie et al. BMC Pediatrics 2010 10:15   doi:10.1186/1471-2431-10-15

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