Email updates

Keep up to date with the latest news and content from BMC Ophthalmology and BioMed Central.

Open Access Case report

Is Microsporidial keratitis an emerging cause of stromal keratitis? – a case series study

Geeta K Vemuganti1*, Prashant Garg2, Savitri Sharma3, Joveeta Joseph3, Usha Gopinathan3 and Shashi Singh4

Author Affiliations

1 Ophthalmic Pathology Service, L.V. Prasad Eye Institute, Hyderabad, India

2 Cornea Service, L.V. Prasad Eye Institute, Hyderabad, India

3 Jhaveri Microbiology Centre, L.V. Prasad Eye Institute, Hyderabad, India

4 Centre for Cellular and Molecular Biology, Hyderabad, India

For all author emails, please log on.

BMC Ophthalmology 2005, 5:19  doi:10.1186/1471-2415-5-19

Published: 17 August 2005

Abstract

Background

Microsporidial keratitis is a rare cause of stromal keratitis. We present a series of five cases of microsporidial keratitis from a single centre in southern India with microbiologic and histopathologic features.

Case presentation

Patient charts of five cases of microsporidial stromal keratitis diagnosed between January 2002 and June 2004 were reviewed retrospectively for clinical data, microbiologic and histopathologic data. The presence of microsporidia was confirmed by special stains on corneal scrapings and/or corneal tissues, and electron microscopy. All patients were immunocompetent with a preceding history of trauma in three. Four patients presented with unilateral, small, persisting deep stromal infiltrates, of uncertain etiology, in the cornea, which were not responding to conventional antimicrobial treatment and required penetrating keratoplasty in three. Fifth case was unsuspected and underwent keratoplasty for post-traumatic scar. Three of five cases were diagnosed on corneal scrapings, prior to keratoplasty, while two were diagnosed only on histology. The microsporidia appeared as oval well defined bodies with dense staining at one pole. None of the patients showed recurrence following keratoplasty.

Conclusion

Microsporidia, though rare, should be suspected in chronic culture-negative stromal keratitis. Organisms could lie dormant without associated inflammation.