Table 1

Effects of Topical fluoroquinolones on Collagenase-type Metalloproteinases Immunohistochemical detection at 48 Hours

Type of eye drops

MMP-1

MMP-8

Applied q.i.d.

Epithelium

Artificial Tear

Intact

0/14

0/14

Debrided

14/14

13/14

Ciloxan

Intact

14/14 **

13/14 **

Debrided

14/14

14/14

Ocuflox

Intact

13/14**

12/14**

Debrided

14/14

14/14

Quixin

Intact

13/14**

12/14**

Debrided

14/14

14/14

Double masked observer determined the total positive immunostained eyes for MMP-1 and MMP-8 in each test group. Immunoreactivity is reported as number of positively immunostained corneas / total number of corneas examined. ** Statistically different when comparing the corresponding fluoroquinolone group to artificial tear. (P < 0.05 using Fisher's exact test analysis).

Reviglio et al. BMC Ophthalmology 2003 3:10   doi:10.1186/1471-2415-3-10