Open Access Open Badges Case report

Case of recurrence of spiradenoma in palpebral conjunctiva

Shinya Oie1, Akira Sawada1*, Kiyofumi Mochizuki1, Kozue Tsuji1, Yoshinobu Hirose2, Chiemi Saigo3 and Hiroshi Yoshikawa3

Author Affiliations

1 Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi 501-1194, Japan

2 Department of Pathology, Gifu University School of Medicine, 1-1 Yanagido, Gifu-shi 501-1194, Japan

3 Department of Ophthalmology, Graduate School of Medical Science, Kyushu University, Fukuoka 812-8582, Japan

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BMC Ophthalmology 2014, 14:85  doi:10.1186/1471-2415-14-85

Published: 27 June 2014



To report a rare case of a recurrence of spiradenoma that developed in the upper eyelid.

Case presentation

A 49-year-old woman who had a second recurrence of a tumor in the right palpebral conjunctiva underwent local resection of the lesion with adjunctive cryotherapy to the surgical site. The tumor consisted of smooth, round to oval nodular lesions approximately 1–3 mm in size with enlarged blood vessels. Histopathologically, the solid and well-circumscribed nodule was located beneath the conjunctival epithelium. It was composed of cells with slightly basophilic-to-clear cytoplasm and round-to-oval nuclei arranged in a trabecular pattern. Periodic acid-Schiff stain was positive in the cytoplasm, and the staining disappeared after digesting by diastase. Many cells in mitosis were observed throughout the tumor but no necrotic cells. Immunohistochemistry showed that the Ki-67 labeling index was 12%. From these findings, we diagnosed this tumor as a recurrence of the spiradenoma. There has been no recurrence and no signs of malignancy in the 6 months after the surgical excision.


Our findings indicate that a spiradenoma should be completely excised surgically because of malignant transformation after repeated recurrences.

Spiradenoma; Sweat gland; Eyelids; Repeated recurrences; Immunohistochemistry