Open Access Highly Accessed Research article

Clinical and microbiological profile of infectious keratitis in children

Patricia Chirinos-Saldaña1, Victor Manuel Bautista de Lucio2, Julio Cesar Hernandez-Camarena1, Alejandro Navas1, Arturo Ramirez-Miranda1, Lizet Vizuet-Garcia2, Mariana Ortiz-Casas2, Nadia Lopez-Espinosa2, Carolina Gaona-Juarez2, Luis Antonio Bautista-Hernandez2 and Enrique O Graue-Hernandez1*

Author Affiliations

1 Cornea and Refractive Surgery Department, Institute of Ophthalmology “Fundación de Asistencia Privada Conde de Valenciana”, Mexico City, Mexico

2 Microbiology and Ocular Proteomics, Research Unit, Institute of Ophthalmology “Fundación de Asistencia Privada Conde de Valenciana”, Mexico City, Mexico

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BMC Ophthalmology 2013, 13:54  doi:10.1186/1471-2415-13-54

Published: 16 October 2013

Abstract

Background

Infectious keratitis is a sight-threatening condition for children. The purpose of this study was to describe the clinical profile, risk factors and microbiological profile of infectious keratitis in children.

Methods

Retrospective review of clinical records of patients under 16 years of age with history of microbial keratitis seen at a tertiary referral center. Clinical characteristics, risk factors, visual and surgical outcomes as well as the microbiological profile are analyzed.

Results

Forty-one eyes of 41 patients. Mean age was 8.7 years. Time between the onset of symptoms and ophthalmological examination was 12.7 days. Predisposing factors were found in 78%; ocular trauma was the most common (25%). Visual acuity equal or worse than 20/200 at admission correlated positively with a poorer visual outcome, p=0.002. Positivity of cultures was 34%. Gram-positive bacteria were isolated in 78.5%; Staphylococcus epidermidis (28.6%) was the most common microorganism.

Conclusions

Our study emphasizes the importance of a prompt diagnosis and treatment of infectious corneal ulcers in children. Trauma and contact lenses were the main predisposing factors. Gram-positive organisms were isolated in the vast majority of cases and visual outcomes are usually poor.

Keywords:
Paediatrics; Children; Drug-resistance; Microbial; Risk factors