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Open Access Highly Accessed Research article

Changes of macular sensitivity and morphology after pars plana vitrectomy for macular edema with central retinal vein occlusion: a case series

Hidetaka Noma1*, Tatsuya Mimura2 and Katsunori Shimada3

Author affiliations

1 Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women’s Medical University, 477-96, Owada-shinden, Yachiyo, Chiba, 276-8524, Japan

2 Department of Ophthalmology, Medical Center East, Tokyo Women’s Medical University, Tokyo, Japan

3 Department of Biostatistics, STATZ Institute Inc, Tokyo, Japan

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Citation and License

BMC Ophthalmology 2013, 13:2  doi:10.1186/1471-2415-13-2

Published: 5 February 2013

Abstract

Background

It is unclear how retinal ischemia influences the changes of visual acuity, macular sensitivity, macular thickness, and macular volume after the performance of pars plana vitrectomy (PPV) for macular edema in patients with central retinal vein occlusion (CRVO).

Methods

Ten patients (10 eyes) with CRVO and macular edema underwent PPV. Retinal ischemia was evaluated from the area of capillary nonperfusion on fluorescein angiography, and the patients were classified into ischemic or nonischemic groups. Microperimetry was performed with a Micro Perimeter 1. Macular thickness and volume were measured by optical coherence tomography.

Results

In both groups, the mean macular thickness within the central 4°, 10°, and 20° fields decreased significantly from baseline to 3 and 6 months after PPV (all P < 0.05). In the ischemic group, the mean macular sensitivity within the central 4°, 10°, and 20° fields increased from baseline to 3 and 6 months after PPV, but no significant difference was observed.

Conclusions

These results suggest that PPV may be effective for improving macular thickness, volume, and sensitivity in patients with macular edema secondary to ischemic CRVO, although there was no significant difference.