Table 1

Demographics and baseline characteristics
Latanoprost concentration (μg/mL)
50 75 100 125
ITT Population, N 71 70 72 69
Sex, n (%)
 Male 32 (45.1) 35 (50.0) 42 (58.3) 35 (50.7)
 Female 39 (54.9) 35 (50.0) 30 (41.7) 34 (49.3)
Race, n (%)
 Caucasian 56 (78.9) 57 (81.4) 55 (76.4) 56 (81.2)
 Black 1 (1.4) 0 (0) 2 (2.8) 1 (1.4)
 Asian 14 (19.7) 13 (18.6) 15 (20.8) 12 (17.4)
Age (years)
 Mean ± SD 59.5 ± 12.8 59.5 ± 12.0 60.6 ± 13.8 61.2 ± 12.7
 Median 61.0 59.0 60.5 63.0
 Range 20-82 26-85 20-85 26-89
Study eye, n (%)
 Right 16 (22.5) 15 (21.4) 13 (18.1) 11 (15.9)
 Left 8 (11.3) 8 (11.4) 11 (15.3) 16 (23.2)
 Both 47 (66.2) 47 (67.1) 48 (66.7) 42 (60.9)
Treated eye, n (%)
 Right 7 (9.9) 5 (7.1) 3 (4.2) 4 (5.8)
 Left 1 (1.4) 1 (1.4) 2 (2.8) 4 (5.8)
 Both 63 (88.7) 64 (91.4) 67 (93.1) 61 (88.4)
Worse eye, n (%)
 Right 50 (70.4) 43 (61.4) 39 (54.2) 36 (52.2)
 Left 21 (29.6) 27 (38.6) 33 (45.8) 33 (47.8)
Eye color, n (%)
 Homogenous blue, gray or green 8 (11.3) 11 (15.7) 4 (5.6) 11 (15.9)
 Homogenous brown 45 (63.4) 43 (61.4) 46 (63.9) 40 (58.0)
 Blue-brown or gray-brown 10 (14.1) 12 (17.1) 11 (15.3) 11 (15.9)
 Green-brown 4 (5.6) 3 (4.3) 8 (11.1) 4 (5.8)
 Yellow-brown 3 (4.2) 1(1.4) 3 (4.2) 3 (4.3)
 Different* 1 (1.4) 0 (0.0) 0 (0.0) 0 (0.0)
Diagnosis, n (%)
 Primary open-angle glaucoma 53 (74.6) 44 (62.9) 47 (65.3) 47 (68.1)
 Ocular hypertension 16 (22.5) 18 (25.7) 21 (29.2) 16 (23.2)
 Different* 2 (2.8) 8 (11.4) 4 (5.6) 6 (8.7)
IOP-lowering medication at
screening, n%
 Alpha agonists 3 (4.2) 5 (7.1) 6 (8.3) 1 (1.4)
 Beta-blockers 33 (46.5) 28 (40.0) 26 (36.1) 23 (33.3)
 Carbonic anhydrase inhibitors 7 (9.9) 8 (11.4) 2 (2.8) 2 (2.9)
 Combination drugs 9 (12.7) 6 (8.6) 4 (5.6) 5 (7.2)
 Parasympathomimetics 0 (0.0) 1 (1.4) 0 (0.0) 2 (2.9)
 Prostaglandins 23 (32.4) 19 (27.1) 20 (27.8) 20 (29.0)
 Sympathomimetics 1 (1.4) 1 (1.4) 0 (0.0) 0 (0.0)
PP Population, N 69 66 71 68
Baseline IOP
Worse eye8 a.m.
 Mean ± SD 26.9 ± 3.1 26.6 ± 3.0 26.5 ± 2.5 26.8 ± 2.8
 Range 24.0 – 36.0 24.0 – 36.0 24.0 – 35.0 24.0 – 36.0
4 p.m.
 Mean ± SD 25.3 ± 3.6 24.6 ± 3.5 25.3 ± 3.1 25.7 ± 3.7
 Range 16.5 – 37.0 15.0 –35.0 17.5 – 34.0 18.0 – 36.0
Study eye
8 a.m.
 Mean ± SD 26.5 ± 2.8 26.1 ± 2.5 26.2 ± 2.4 26.4 ± 2.4
 Range 24.0 – 34.0 24.0 – 36.0 24.0 – 35.0 24.0 – 34.0
4 p.m.
 Mean ± SD 25.1 ± 3.4 24.3 ± 3.1 25.1 ± 2.9 25.3 ± 3.3
 Range 16.5 – 35.0 15.5 – 34.0 18.0 – 34.0 18.0 – 36.0

IOP intraocular pressure, ITT intention-to-treat, PP per protocol, SD standard deviation.

*If the diagnosis/eye color of a subjects eye was not the same in both eyes, the outcome was given as different.

By subject (i.e. diagnoses for both eyes of the subject were combined).

Eveleth et al.

Eveleth et al. BMC Ophthalmology 2012 12:9   doi:10.1186/1471-2415-12-9

Open Data