Table 6

directionality P values

Sample

2D

3D Ctrl

Wt 10 nM

Wt 50 nM

mAb13

mAb13 + Wt 10 nM

mAb13 Wt 50 nM


untreated

Ctrl

< 0.0014**

-

0.0219*

< 0.0001***

    0.2395

    0.6252

0.0377*

TA

< 0.0001***

0.0109*

    0.6641

    0.5551

< 0.0001***

< 0.0001***

< 0.0001***


Wt 10 nM

Ctrl

-

-

-

    0.3691

    0.0545

0.0109*

    0.1144

TA

-

-

-

    0.3983

< 0.0001***

< 0.0001***

< 0.0001***


Wt 50 nM

Ctrl

-

-

-

-

0.0002***

< 0.0001***

0.0004***

TA

-

-

-

-

< 0.0001***

< 0.0001***

< 0.0001***


mAb13

Ctrl

-

-

-

-

-

    0.2808

    0.5132

TA

-

-

-

-

-

    0.4318

    0.2500


mAb13 + Wt 10 nM

Ctrl

-

-

-

-

-

-

    0.0568

TA

-

-

-

-

-

-

    0.8769


P values were obtained using Mann-Whitney test. Non-significant values are underlined while relative significance levels are designated as extremely***, very**, or significant*. Bolded data represent conditions in which differences were observed between control and tumor-associated 3D matrix induced directionality due to stated treatments.

Castell√≥-Cros et al. BMC Cancer 2009 9:94   doi:10.1186/1471-2407-9-94

Open Data