Open Access Highly Accessed Research article

Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins

Remedios Castelló-Cros, David R Khan, Jeffrey Simons, Matthildi Valianou and Edna Cukierman*

Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, PA 19111-2497, USA

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BMC Cancer 2009, 9:94 doi:10.1186/1471-2407-9-94

Published: 26 March 2009

Additional files

Additional file 1:

Normal cell motility through staged 3D ECMs. Montage of six hour time-lapse videos depicting MCF-10A cells moving through control (top left) and tumor-associated (top right) 3D ECMs or on 2D (bottom left).

Format: MOV Size: 18.2MB Download file

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Additional file 2:

Tumorigenic cell motility through staged 3D ECMs. Montage of six hour time-lapse videos depicting MCF-7 cells moving through control (top left) and tumor-associated (top right) 3D ECMs or on 2D (bottom left).

Format: MOV Size: 14.7MB Download file

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Additional file 3:

Invasive cell motility through staged 3D ECMs. Montage of six hour time-lapse videos depicting MDA-MB-231 cells moving through control (top left) and tumor-associated (top right) 3D ECMs or on 2D (bottom left).

Format: MOV Size: 15.1MB Download file

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Additional file 4:

Invasive cell motility through control 3D ECMs under PI3K and/or beta-1 integrin inhibition. Montage of six hour time-lapse videos depicting MDA-MB-231 cells invading through control 3D ECMs (top left) in the presence of 10 nM Wortmannin (top right), 50 μg/ml mAb13 (bottom left) or a combination of both mAb13 and 10 nM Wortmannin (bottom right).

Format: MOV Size: 19MB Download file

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Additional file 5:

Invasive cell motility through tumor-associated 3D ECMs under PI3K and/or beta-1 integrin inhibition. Montage of six hour time-lapse videos depicting MDA-MB-231 cells invading through tumor-associated 3D ECMs (top left) in the presence of 10 nM Wortmannin (top right), 50 μg/ml mAb13 (bottom left) or a combination of both mAb13 and 10 nM Wortmannin (bottom right).

Format: MOV Size: 18MB Download file

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Open Data

Additional file 6:

Invasive cell motility through staged 3D ECMs under PI3K and/or beta-1 integrin inhibition. Montage of six hour time-lapse videos depicting MDA-MB-231 cells within 3D control (bottom panels) or tumor-associated (top panels) matrices, in the presence of 50 nM Wortmannin alone (left panels) or in combination with 50 μg/ml mAb13 (right panels).

Format: MOV Size: 18.3MB Download file

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Open Data