Perforated block in the stroma: multiple rounds. The Initial State represents stable tissue architecture when a solid block is first inserted into the stroma. A round is one cycle of cell movement and morphostat update through all the cells. At Round 5 scattered aberrant cells form above top layer cells, which persists through later rounds.
Baker et al. BMC Cancer 2009 9:89 doi:10.1186/1471-2407-9-89