Solid block in the stroma: snapshots. Panel A shows stable tissue architecture and a stable morphostat gradient when a block has been inserted in the stroma. In Panel B some top-layer cells have sloughed off and were replaced by middle layer cells, some middle layers cells have moved upward leaving open spaces, and one top layer cell has become aberrant due to experiencing a morphostat level below the Level 0 threshold. In Panel C, middle layer cells on top have become top layer cells due to reaching the threshold morphostat Level 0.
Baker et al. BMC Cancer 2009 9:89 doi:10.1186/1471-2407-9-89