No block in the stroma: snapshots. Panel A shows stable tissue architecture and a stable morphostat gradient. In Panel B some top-layer cells have sloughed off and were replaced by middle layer cells, and some middle layers cells have moved upward leaving open spaces. In Panel C, the middle layer cells on top have become top layer cells because they experienced the threshold Level 0 morphostat concentration; also open spaces on top have been classified as lumen.
Baker et al. BMC Cancer 2009 9:89 doi:10.1186/1471-2407-9-89