Open Access Highly Accessed Research article

Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of morphostats

Stuart G Baker1*, Ana M Soto2, Carlos Sonnenschein2, Antonio Cappuccio3, John D Potter4 and Barnett S Kramer5

Author Affiliations

1 Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, USA

2 Department of Anatomy and Cell Biology, Tufts University School of Medicine, Boston, USA

3 Bioinformatics and Computational Systems Biology of Cancer, Institut Curie, Paris, France

4 Division of Public Health Sciences, Fred Hutchinson Cancer Research, Seattle, USA

5 Office of Disease Prevention, National Institutes of Health, Bethesda, USA

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BMC Cancer 2009, 9:89  doi:10.1186/1471-2407-9-89

Published: 23 March 2009

Additional files

Additional file 1:

Mathematical formulation of rules for cell renewal. The various rules for the movement and differentiation of cells are defined mathematically.

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Additional file 2:

Software for computer simulation. A Mathematica package for the computer simulation is provided.

Format: M Size: 26KB Download file

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