Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of morphostats
1 Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, USA
2 Department of Anatomy and Cell Biology, Tufts University School of Medicine, Boston, USA
3 Bioinformatics and Computational Systems Biology of Cancer, Institut Curie, Paris, France
4 Division of Public Health Sciences, Fred Hutchinson Cancer Research, Seattle, USA
5 Office of Disease Prevention, National Institutes of Health, Bethesda, USA
BMC Cancer 2009, 9:89 doi:10.1186/1471-2407-9-89Published: 23 March 2009
Additional file 1:
Mathematical formulation of rules for cell renewal. The various rules for the movement and differentiation of cells are defined mathematically.
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Additional file 2:
Software for computer simulation. A Mathematica package for the computer simulation is provided.
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