Genes of cell-cell interactions, chemotherapy detoxification and apoptosis are induced during chemotherapy of acute myeloid leukemia

doi:10.1186/1471-2407-9-77

BMC Cancer

Volume 9

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Øyan AM
Ånensen N
Bø TH
Stordrange L
Jonassen I
Bruserud Ø
Kalland KH
Gjertsen BT

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Øyan AM
Ånensen N
Bø TH
Stordrange L
Jonassen I
Bruserud Ø
Kalland KH
Gjertsen BT
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Research article

Genes of cell-cell interactions, chemotherapy detoxification and apoptosis are induced during chemotherapy of acute myeloid leukemia

Anne Margrete Øyan¹^,2 , Nina Ånensen⁵ , Trond Hellem Bø²^,3^,4 , Laila Stordrange³^,4 , Inge Jonassen³^,4 , Øystein Bruserud⁵^,6 , Karl-Henning Kalland¹^,2 and Bjørn Tore Gjertsen⁵^,6

¹The Gade Institute, University of Bergen, Bergen, Norway

²Department of Microbiology and Immunology, Haukeland University Hospital, Bergen, Norway

³Department of Informatics, University of Bergen, Bergen, Norway

⁴Computational Biology Unit, Bergen Center for Computational Science, University of Bergen, Bergen, Norway

⁵Institute of Medicine, Hematology Section, University of Bergen, Bergen, Norway

⁶Department of Medicine, Hematology Section, Haukeland University Hospital, Bergen, Norway

author email corresponding author email

BMC Cancer 2009, 9:77doi:10.1186/1471-2407-9-77


Published:	5 March 2009

Additional files

Additional file 1:

Clinical and biological characteristics of acute myeloid leukemia patients. Table displaying clinical and biological characteristics of acute myeloid leukemia patients

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Additional file 2:

p53-interacting genes expressed in AML blasts following treatment in vivo with anthracycline and cytarabine and ex vivo with anthracycline. Average fold increase of gene expressions in isolated blasts from 7 AML patients 2–4 h (early response) and 18–24 h (late response) following treatment in vivo with anthracyclines according to Oligo DNA arrays, cDNA arrays and TaqMan Low Density Array (T-LDA).

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Additional file 3:

Permuting relationship between GO-terms and genes induced at late response following in vivo chemotherapy. The iterative group analysis was used to analyze whether gene products associated with any term in gene ontology (GO) were over-represented among those found to be significantly regulated for early and late response. Source http://source.stanford.edu webcite. False discovery rates for the list of reported GO-terms were estimated by performing 100 permutations.

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Additional file 4:

Early gene expression signature of chemotherapy treated AML in vivo. The gene expressions of p53-associated genes implicated in the response to oxidative stress, cell cycle arrest, DNA repair, autophagy and apoptosis using standard anthracycline and cytarabine-based chemotherapy are shown. Red colored receptors and nodes represent upregulated genes observed within the first 24 hours of chemotherapy in vivo.

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