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Summary of LOH analysis of FAT gene locus in astrocytic tumors (20 grade II and 20 grade IV) by RFLP using SNP markers. |
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| Summary of LOH detected with each SNP markers |
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| SNP-Markers |
rs22 76930 |
rs37 33414 |
rs45 5600 |
rs21 3090 |
rs45 0320 |
rs76 63350 |
rs11 93110 |
rs12 98865 |
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| Informative samples |
Grade II |
0/20 (0%) |
15/20 (75%) |
7/20 (35%) |
9/20 (45%) |
12/20 (60%) |
7/20 (35%) |
2/20 (10%) |
0/20 (0%) |
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| Grade IV |
0/20 (0%) |
8/20 (40%) |
6/20 (30%) |
6/20 (30%) |
10/20 (50%) |
0/20 (0%) |
2/20 (10%) |
1/20 (5%) |
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| LOH per informative samples |
Grade II |
0/20 (0%) |
2/15 (13.33%) |
2/7 (28.57%) |
3/9 (33.33%) |
4/12 (33.33%) |
0/7 (0%) |
0/2 (0%) |
0/0 (0%) |
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| Grade IV |
0/20 (0%) |
3/8 (37.5%) |
2/6 (33.33%) |
3/6 (50%) |
5/10 (50%) |
0/0 (0%) |
1/2 (50%) |
1/1 (100%) |
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| Total LOH (Grade II & IV) |
0/20 (0%) |
5/23 21.73% |
4/13 30.73% |
6/15 40% |
9/22 40.90% |
0/7 (0%) |
1/4 25% |
1/1 100% |
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| LOH per informative samples |
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| Samples |
Grade II (N = 20) |
Grade IV (N = 20) |
Grade II&IV (N = 40) |
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| Overall SNP LOH per informative samples |
8/19* (42.10%) |
11/19* (57.89%) |
19/38 (50%) |
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And SNP LOH detected per informative samples (Grade II and IV) with all SNP markers. * In both grade II and grade IV one sample each were uninformative with all the SNP markers used. | |||||||||
Chosdol et al. BMC Cancer 2009 9:5 doi:10.1186/1471-2407-9-5 |
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