Table 3

Loss of heterozygosity analysis of the FAT gene with 8 intragenic SNP markers in 20 grade II (A) and 20 grade IV (G) astrocytic tumors.

Low grade Diffuse Astrocytoma (Grade II)

SNP markers

A1

A2

A3

A4

A5

A6

A7

A8

A9

A10

A11

A12

A13

A14

A15

A16

A17

A18

A19

A20

rs2276930

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

rs3733414

NL

NL

U

U

U

L

L

NL

NL

NL

NL

NL

NL

NL

NL

NL

U

NL

NL

U

rs455600

U

U

U

U

U

L

U

NL

NL

U

NL

U

NL

U

U

U

L

NL

U

U

rs213090

NL

NL

U

U

NL

U

L

U

NL

U

NL

U

U

U

U

U

L

NL

L

U

rs450320

U

L

U

L

NL

U

NL

U

L

NL

U

NL

U

NL

NL

NL

U

NL

U

L

rs7663350

NL

NL

U

U

NL

NL

U

U

U

U

U

NL

U

U

U

NL

U

U

U

NL

rs1193110

U

NL

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

NL

U

rs1298865

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

Glioblastoma multiforme (Grade IV)

SNP markers

G1

G2

G3

G4

G5

G6

G7

G8

G9

G10

G11

G12

G13

G14

G15

G16

G17

G18

G19

G20

rs2276930

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

U

rs3733414

U

U

U

U

NL

U

L

U

U

L

L

U

U

NL

NL

U

U

U

NL

NL

rs455600

NL

U

NL

U

U

U

L

U

L

U

NA

NL

U

U

U

U

U

U

U

NL

rs213090

L

L

U

U

U

U

U

NL

U

U

NL

U

NL

U

U

U

U

U

U

L

rs450320

NL

NL

L

L

U

NL

U

L

NA

NL

L

U

U

NL

U

U

L

U

U

U

rs7663350

U

U

NL

U

U

NL

U

U

NL

U

U

U

U

U

U

U

U

NL

NL

NL

rs1193110

U

U

U

U

U

U

U

U

U

L

U

NL

U

U

U

U

U

U

U

U

rs1298865

U

U

U

U

U

U

U

U

U

U

U

L

U

U

U

U

U

U

U

U

L is loss of heterozygosity, NL is no loss of heterozygosity, U is uninformative and NA is not analysed. Loss of heterozygosity was detected in 42% of grade II and 58% of grade IV astrocytic tumors.

Chosdol et al. BMC Cancer 2009 9:5 doi:10.1186/1471-2407-9-5