Table 5 |
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|
Comparison among chemoradiotherapy studies, using nedaplatin/5-FU for esophageal cancer |
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|
A. Daily low-dose nedaplatin and 5-FU regimens |
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|
|
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|
Author |
No. |
Radiation (Gy) |
Total dose (mg) Nedaplatin 5-FU |
Stage |
RR (%) |
CR (%) |
Survival rate (%) |
Leucopenia (%) |
|
|
||||||||
|
Inaba H [37] |
10 |
60 |
200/body 10,000/body |
I--IVB |
80 |
50 |
80 (1 y) |
90 |
|
|
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|
Osawa S * |
33 |
50.4--66 |
200/body 10,000/body |
I--IVB |
90.9 |
60.6 |
83 (1 y) 77 (2 y) |
75.8 |
|
|
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|
B. Intermittent standard-dose nedaplatin and 5-FU regimens |
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|
|
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|
Author |
No. |
Radiation (Gy) |
Total dose (mg) Nedaplatin 5FU |
Stage |
RR (%) |
CR (%) |
Survival rate (%) |
Leucopenia (%) |
|
|
||||||||
|
Kato H [38] |
22 |
60--66 |
160/m2 5,000/m2 |
I--IV |
77 |
9 |
30.7 (1 y) 10.2 (2 y) |
15.4 |
|
|
||||||||
|
17 |
40 |
80/m2 25,000/m2 |
pre-S II--IV |
70.6 |
28.6 |
48.2 (1 y) 12.1 (2 y) |
||
|
|
||||||||
|
Yamanaka H [39] |
17 |
40 |
200/body 14,000/body |
I--IVB |
76.5 |
11.8 |
52.9 (1 y) |
17.6 |
|
|
||||||||
|
Nemoto K [40] |
17 |
60--70 |
200/body 15,000/body |
I--IVA |
94.1 |
41.2 |
59 (1 y) 39 (2 y) |
25 |
|
|
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|
7 |
60--70 |
200/body 15,000/body |
post-S recur |
100 |
0 |
69 (1 y) 69 (2 y) |
||
|
|
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|
Ishikura S [14] |
26 |
60 |
180/m2 8,000/m2 |
III--IVB |
--- |
12 |
50 (1 y) 31 (2 y) |
35 |
|
|
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|
Sato Y [12] |
26 |
60 |
100/m2 4,000/m2 |
I--IVA |
88.5 |
42.3 |
65.1 (1 y) 37.2 (3 y) |
40 |
|
|
||||||||
|
Kodaira T [13] |
40 |
60 |
360/m2 10,500/m2 |
III--IV |
76 |
48 |
58.9 (1 y) 45.9 (2 y) |
80 |
|
|
||||||||
|
Yamashita H [41] |
12 |
50.4 |
160/m2 6,400/m2 |
II--IVB |
82 |
73 |
40 (1 y) 13 (2 y) |
50 |
|
|
||||||||
|
Jingu K [42] |
30 |
60 |
140/m2 5,000/m2 |
post-S recur |
73.3 |
13.3 |
60.6 (1 y) 56.3 (3 y) |
30 |
|
|
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|
*, present study; RR, response rate; CR, complete response; pre-S, pre-surgical; post-S recur, post-surgical recurrence; 1 y, 1-year; 2 y, 2-year |
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|
Osawa et al. BMC Cancer 2009 9:408 doi:10.1186/1471-2407-9-408 |
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