Table 3

Incidence rate ratio for colorectal cancer for combinations of MDR1 genotypes

IRRa (95% CI) (Ncase/Nsub-cohort)


MDR1 C3435T

MDR1 G-rs3789243-A

CC

CT

TT

GG

1.38

(0.31-6.15)

1.16

(0.66-2.06)

1.00b

-

Ncase/Nsub-cohort

(3/6)

(27/68)

(52/153)

GA

2.20

(1.22-3.96)

1.52

(1.01-2.29)

1.72

(1.06-2.81)

Ncase/Nsub-cohort

(32/42)

(110/234)

(55/92)

AA

1.80

(1.06-3.05)

1.38

(0.82-2.32)

1.48

(0.58-3.75)

Ncase/Nsub-cohort

(39/72)

(38/85)

(8/20)


a Adjusted for status of HRT, smoking status, alcohol, dietary fibre, red meat and BMI.

bThe most prevalent double homozygous genotype was used as reference.

Andersen et al. BMC Cancer 2009 9:407   doi:10.1186/1471-2407-9-407

Open Data