Table 1 |
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|
Genotypes of the Int7G24A polymorphism in cases and controls and their association with CRC. |
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|
Int7G24A genotype |
Cases (n = 504) |
Controls (n = 504) |
OR [95% CI] |
p |
|
|
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|
Dominant model |
number (%) |
number (%) |
||
|
G/G |
296 (58.73) |
333 (66.07) |
1 (ref) |
|
|
G/A and A/A |
208 (41.27) |
171 (33.93) |
1.37 [1.06-1.77] |
0.019* |
|
Additive model |
||||
|
G/G |
296 (58.73) |
333 (66.07) |
1 (ref) |
|
|
G/A |
178(35.32) |
156 (30.95) |
1.28 [0.98-1.67] |
|
|
A/A |
30 (5.95) |
15 (2.98) |
2.25 [1.20-4.23] |
0.005** |
|
Recessive model |
||||
|
G/G and G/A |
474 (94.05) |
489 (97.02) |
1 (ref) |
|
|
A/A |
30 (5.95) |
15 (2.98) |
2.04 [1.11-3.85] |
0.032* |
|
≤ 70 yrs (n = 213) |
≤ 70 yrs (n = 219) |
|||
|
G/G, number (%) |
118 (55.40) |
150 (68.49) |
1 (ref) |
|
|
G/A, number (%) |
80 (37.56) |
61 (27.85) |
1.67 [1.11-2.51] |
|
|
A/A, number (%) |
15 (7.04) |
8 (3.65) |
2.38 [1.00-5.68] |
0.004** |
|
>70 yrs (n = 227) |
>70 yrs (n = 284) |
|||
|
G/G, number (%) |
145 (63.88) |
182 (64.08) |
1 (ref) |
|
|
G/A, number (%) |
72 (31.72) |
95 (33.45) |
0.95 [0.65-1.39] |
|
|
A/A, number (%) |
10 (4.41) |
7 (2.46) |
1.79 [0.69-4.67] |
0.662** |
|
males (n = 295) |
males (n = 226) |
|||
|
G/G, number (%) |
166 (56.27) |
160 (70.80) |
1 (ref) |
|
|
G/A, number (%) |
112 (37.97) |
62 (27.43) |
1.74 [1.19-2.54] |
|
|
A/A, number (%) |
17 (5.76) |
4 (1.77) |
4.10 [1.41-11.85] |
0.00023** |
|
females (n = 202) |
females (n = 277) |
|||
|
G/G, number (%) |
126 (62.38) |
172 (62.09) |
1 (ref) |
|
|
G/A, number (%) |
63 (31.19) |
94 (33.94) |
0.92 [0.62-1.36] |
|
|
A/A, number (%) |
13 (6.44) |
11 (3.97) |
1.61 [0.71-3.65] |
0.688** |
|
|
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|
* χ2 test; ** p for trend (Armitage's trend test) |
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|
Castillejo et al. BMC Cancer 2009 9:406 doi:10.1186/1471-2407-9-406 |
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