Research article
Partial loss of heterozygosity events at the mutated gene in tumors from MLH1/MSH2 large genomic rearrangement carriers
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* Corresponding author: Zdena Bartosova exonbar@savba.sk
1 Laboratory of Cancer Genetics, Cancer Research Institute of Slovak Academy of Sciences, Vlarska 7, 833 91 Bratislava, Slovak Republic
2 National Cancer Institute, Department of Oncologic Genetics, Klenova 1, 833 01 Bratislava, Slovak Republic
BMC Cancer 2009, 9:405 doi:10.1186/1471-2407-9-405
Published: 20 November 2009Additional files
Additional file 1:
LOH analysis by the microsatellite marker D3S1611 in SK-22 patient. An example of tumor with LOH at the D3S1611 marker, Retention of heterozygosity at the D3S1611 marker in tumor of SK-22 patient.
Format: TIFF Size: 1.4MB Download file
Additional file 2:
Data from LOH analyses by MLPA. Table of the average dosage quotients of exons affected by LGR in matched normal and tumor DNA of patients with identified LGRs in the MLH1 or MSH2 genes and calculated LOH ratios.
Format: DOC Size: 30KB Download file
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Additional file 3:
Data from LOH analyses by MLPA. Table of the signal intensities of SNP alleles in matched normal and tumor DNA in the patients with identified LGRs in the MLH1 or MSH2 genes and calculated LOH ratios.
Format: DOC Size: 78KB Download file
This file can be viewed with: Microsoft Word Viewer