Table 1

Relationships between expression of E-cadherin, Slug and GSK3β in IDCs of breast: Correlation with clinicopathological parameters

Parameter

Total Cases (N)

E-Cad (Mem)

E-Cad (Cyto)

Slug (Nucl)

Gsk3β (Nucl)

Gsk3β (Cyto)


-

+

P

-

+

P

-

+

P

-

+

P

-

+

P


98

53

45

46

52

65

33

64

34

52

46


Age

ὄ 50

62

30

32

.148

24

38

0.06

40

22

.663

44

18

0.131

30

32

.294

>50

36

23

13

22

14

25

11

20

16

22

14


Menopausal status

Pre-

35

19

16

1.00

12

23

0.091

22

13

.658

27

8

.079

19

16

1.00

Post-

63

34

29

34

29

43

20

37

26

33

30


Tumor grade

T1+T2

53

24

29

.060

21

32

0.155

29

24

.01*1

29

24

.02*2

26

27

.422

T3+T4

45

29

16

25

20

36

9

35

10

26

19


Lymphatic involvement

N0

36

19

17

1.00

18

18

0.679

22

14

.507

20

16

0.131

18

18

.675

N1-2

62

34

28

28

34

43

19

44

18

34

28


Grade

I+II

56

27

29

.221

22

34

0.103

33

23

.087

32

24

.05*3

31

25

.684

III+IV

42

26

16

24

18

32

10

32

10

21

21


ER

+ve

28

17

11

.502

13

15

1.00

15

13

.103

13

15

.019*4

17

11

.377

-ve

70

36

34

33

37

50

20

51

19

35

35


*TNM Classification on basis of AJCC classification [46]. Abbreviations: E-cad, E-cadherin; Cyto, Cytoplasmic; Nucl, Nuclear and Mem, Membrane. *1p = 0.01; OR = 0.191 [95% CI = 0.122-0.75]; *2p = 0.02; OR = 0.3 [95%CI = 0.142-0.838]; *3p = 0.05; OR = 0.417 [95%CI = 0.172-1.01]; *4p = 0.019; OR = 3.09 [95%CI= 1.24-7.09]. * p values were calculated using Fischer exact test. p < 0.05 was considered as significant and are given in the table. Analysis of relationships between E-cadherin, Slug and GSK3β expression in IDCs showed the following significant associations: E-cad (Mem)-/Slug (Nucl)+: p = 0.001; OR = 4.49 [95% C.I = 1.82-11.8]; E-cad (Cyto)+/E-cad (Mem)-: p = 0.016; OR = 2.82 [95% C.I = 1.23-6.44]; E-cad (Cyto)+/Slug (Nucl)+: p = 0.031; OR = 2.88 [95% C.I = 1.17-6.95]; GSK3β (Cyto)+/GSK3β (Nucl)+: p = 0.012; OR = 3.06 [95% CI = 1.28-7.27].

Prasad et al. BMC Cancer 2009 9:325   doi:10.1186/1471-2407-9-325

Open Data