Table 1 |
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|
Relationships between expression of E-cadherin, Slug and GSK3β in IDCs of breast: Correlation with clinicopathological parameters |
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|
Parameter |
Total Cases (N) |
E-Cad (Mem) |
E-Cad (Cyto) |
Slug (Nucl) |
Gsk3β (Nucl) |
Gsk3β (Cyto) |
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|
|
||||||||||||||||
|
- |
+ |
P |
- |
+ |
P |
- |
+ |
P |
- |
+ |
P |
- |
+ |
P |
||
|
|
||||||||||||||||
|
98 |
53 |
45 |
46 |
52 |
65 |
33 |
64 |
34 |
52 |
46 |
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|
|
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|
Age |
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|
ὄ 50 |
62 |
30 |
32 |
.148 |
24 |
38 |
0.06 |
40 |
22 |
.663 |
44 |
18 |
0.131 |
30 |
32 |
.294 |
|
>50 |
36 |
23 |
13 |
22 |
14 |
25 |
11 |
20 |
16 |
22 |
14 |
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|
|
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|
Menopausal status |
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|
Pre- |
35 |
19 |
16 |
1.00 |
12 |
23 |
0.091 |
22 |
13 |
.658 |
27 |
8 |
.079 |
19 |
16 |
1.00 |
|
Post- |
63 |
34 |
29 |
34 |
29 |
43 |
20 |
37 |
26 |
33 |
30 |
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|
|
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|
Tumor grade |
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|
T1+T2 |
53 |
24 |
29 |
.060 |
21 |
32 |
0.155 |
29 |
24 |
.01*1 |
29 |
24 |
.02*2 |
26 |
27 |
.422 |
|
T3+T4 |
45 |
29 |
16 |
25 |
20 |
36 |
9 |
35 |
10 |
26 |
19 |
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|
|
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|
Lymphatic involvement |
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|
N0 |
36 |
19 |
17 |
1.00 |
18 |
18 |
0.679 |
22 |
14 |
.507 |
20 |
16 |
0.131 |
18 |
18 |
.675 |
|
N1-2 |
62 |
34 |
28 |
28 |
34 |
43 |
19 |
44 |
18 |
34 |
28 |
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|
|
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|
Grade |
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|
I+II |
56 |
27 |
29 |
.221 |
22 |
34 |
0.103 |
33 |
23 |
.087 |
32 |
24 |
.05*3 |
31 |
25 |
.684 |
|
III+IV |
42 |
26 |
16 |
24 |
18 |
32 |
10 |
32 |
10 |
21 |
21 |
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|
|
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|
ER |
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|
+ve |
28 |
17 |
11 |
.502 |
13 |
15 |
1.00 |
15 |
13 |
.103 |
13 |
15 |
.019*4 |
17 |
11 |
.377 |
|
-ve |
70 |
36 |
34 |
33 |
37 |
50 |
20 |
51 |
19 |
35 |
35 |
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|
|
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|
*TNM Classification on basis of AJCC classification [46]. Abbreviations: E-cad, E-cadherin; Cyto, Cytoplasmic; Nucl, Nuclear and Mem, Membrane. *1p = 0.01; OR = 0.191 [95% CI = 0.122-0.75]; *2p = 0.02; OR = 0.3 [95%CI = 0.142-0.838]; *3p = 0.05; OR = 0.417 [95%CI = 0.172-1.01]; *4p = 0.019; OR = 3.09 [95%CI= 1.24-7.09]. * p values were calculated using Fischer exact test. p < 0.05 was considered as significant and are given in the table. Analysis of relationships between E-cadherin, Slug and GSK3β expression in IDCs showed the following significant associations: E-cad (Mem)-/Slug (Nucl)+: p = 0.001; OR = 4.49 [95% C.I = 1.82-11.8]; E-cad (Cyto)+/E-cad (Mem)-: p = 0.016; OR = 2.82 [95% C.I = 1.23-6.44]; E-cad (Cyto)+/Slug (Nucl)+: p = 0.031; OR = 2.88 [95% C.I = 1.17-6.95]; GSK3β (Cyto)+/GSK3β (Nucl)+: p = 0.012; OR = 3.06 [95% CI = 1.28-7.27]. |
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|
Prasad et al. BMC Cancer 2009 9:325 doi:10.1186/1471-2407-9-325 |
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