Table 4 |
||||||||||
|
FH of malignant tumor in first degree relatives and survival from UGI cancer * |
||||||||||
|
ESCC |
GCA |
GNCA |
||||||||
|
FH |
Case |
Death |
HR (95% CI) |
Case |
Death |
HR (95% CI) |
Case |
Death |
HR (95% CI) |
|
|
|
||||||||||
|
Any malignant tumor |
- |
379 |
232 |
1 |
384 |
278 |
1 |
210 |
134 |
1 |
|
+ |
190 |
113 |
1.09(0.86–1.36) |
146 |
96 |
0.80(0.63–1.01) |
85 |
60 |
1.22(0.88–1.68) |
|
|
|
||||||||||
|
Any UGI cancer |
- |
443 |
268 |
1 |
434 |
309 |
1 |
245 |
164 |
1 |
|
+ |
126 |
77 |
1.06(0.82–1.38) |
96 |
65 |
0.82(0.62–1.08) |
50 |
30 |
0.85(0.56–1.28) |
|
|
0 affected |
- |
443 |
268 |
1 |
434 |
309 |
1 |
245 |
164 |
1 |
|
1 affected |
+ |
109 |
69 |
1.15(0.88–1.50) |
82 |
55 |
0.80(0.60–1.07) |
43 |
23 |
0.73(0.46–1.15) |
|
≥2 affected |
+ |
17 |
8 |
0.64(0.32–1.30) |
14 |
10 |
0.94(0.48–1.84) |
7 |
7 |
1.82(0.84–3.97) |
|
<50 |
+ |
23 |
19 |
1.82(1.01–3.29) |
8 |
7 |
2.30(0.85–6.20) |
16 |
8 |
0.96(0.38–2.38) |
|
>=50 |
+ |
103 |
58 |
0.92(0.68–1.22) |
88 |
58 |
0.76(0.57–1.02) |
34 |
22 |
0.78(0.49–1.26) |
|
|
||||||||||
|
Esophageal cancer |
- |
479 |
291 |
1 |
481 |
342 |
1 |
268 |
174 |
1 |
|
+ |
90 |
54 |
0.97(0.72–1.31) |
49 |
32 |
0.81(0.56–1.18) |
27 |
20 |
1.03(0.63–1.68) |
|
|
Gastric cardia cancer |
- |
546 |
327 |
1 |
504 |
356 |
1 |
284 |
189 |
1 |
|
+ |
23 |
18 |
1.61(0.99–2.61) |
26 |
18 |
0.88(0.54–1.42) |
11 |
5 |
0.66(0.26–1.64) |
|
|
Gastric noncardia cancer |
- |
550 |
336 |
1 |
503 |
356 |
1 |
279 |
185 |
1 |
|
+ |
19 |
9 |
0.80(0.41–1.56) |
27 |
18 |
0.76(0.47–1.22) |
16 |
9 |
0.96(0.48–1.91) |
|
|
|
||||||||||
|
Non-UGI cancer |
- |
505 |
309 |
1 |
480 |
343 |
1 |
260 |
164 |
1 |
|
+ |
64 |
36 |
1.10(0.77–1.56) |
50 |
31 |
0.82(0.56–1.20) |
35 |
30 |
1.73(1.16–2.60) |
|
|
|
||||||||||
|
*HRs adjusted for age, gender, geographic region, histologic grade, primary tumor stage, and lymph node metastatsis |
||||||||||
|
Gao et al. BMC Cancer 2009 9:269 doi:10.1186/1471-2407-9-269 |
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