Figure 1.

Geographical distribution of BRCA1-2 mutations carriers in Sardinia. Symbols indicate villages of origin for the patients presenting deleterious germline mutations in either BRCA1 or BRCA2 genes: "green square" BRCA1 c.300 T>G; green circle BRCA1 c.916_917delTT; "green triangle" BRCA1 c.1099_1100delCA; "green arrow" BRCA1c.1499insA; "green heart"BRCA1 c.1632 A>T; "green diamond" BRCA1 c.1638 A>T;"green clubs" BRCA1 c.3823_3826delACAA; "green spades" BRCA1 c.4575delA; "blue square" BRCA2 c.3950_3952delTAGinsAT; "blue triangle" BRCA2 c.6586 C>G; "blue circle" BRCA2 c.6023_6024delTA; "blue arrow" BRCA2 c.8764_8765delAG; "blue heart"BRCA2 c.8559+1G>T. Dashed lines delimit the three geographical regions reported in the text.