Table 2 |
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|
NFKBIA and NFKBIB Polymorphisms and Adjusted Risk of Epithelial Ovarian Cancer |
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|
General Model OR (95%CI) |
Ordinal Model OR (95% CI) |
|||||||
|
Gene |
SNP ID |
bp to next |
MAF |
AB v AA |
BB v AA |
p-value |
per-allele |
p-value |
|
|
||||||||
|
NFKBIA |
rs3138055 |
639 |
0.28 |
0.99 (0.81–1.20) |
1.02 (0.72–1.46) |
0.98 |
1.00 (0.87–1.16) |
0.99 |
|
rs696 |
124 |
0.38 |
0.94 (0.77–1.15) |
0.85 (0.64–1.14) |
0.54 |
0.93 (0.81–1.06) |
0.28 |
|
|
rs8904 |
190 |
0.38 |
0.93 (0.76–1.13) |
0.84 (0.63–1.13) |
0.49 |
0.92 (0.80–1.05) |
0.24 |
|
|
rs1022714 |
900 |
0.21 |
0.94 (0.78–1.15) |
0.98 (0.61–1.59) |
0.85 |
0.96 (0.82–1.13) |
0.65 |
|
|
rs3138054 |
485 |
0.17 |
1.18 (0.97–1.44) |
0.97 (0.51–1.85) |
0.26 |
1.13 (0.94–1.35) |
0.19 |
|
|
rs2233415 |
978 |
0.27 |
0.84 (0.69–1.02) |
0.93 (0.65–1.32) |
0.22 |
0.91 (0.78–1.05) |
0.20 |
|
|
rs1957106 |
500 |
0.30 |
0.77 (0.63–0.94) |
0.92 (0.65–1.30) |
0.03 |
0.87 (0.76–1.01) |
0.07 |
|
|
rs2233409 |
253 |
0.23 |
1.11 (0.92–1.35) |
0.93 (0.61–1.40) |
0.48 |
1.04 (0.89–1.21) |
0.61 |
|
|
rs2233407 |
331 |
0.06 |
1.27 (0.96–1.70) |
0.24 (0.04–1.24) |
0.06 |
1.13 (0.86–1.47) |
0.38 |
|
|
rs3138053 |
515 |
0.29 |
1.03 (0.85–1.25) |
1.06 (0.75–1.49) |
0.93 |
1.03 (0.89–1.19) |
0.70 |
|
|
rs3138050 |
2,352 |
0.22 |
1.04 (0.77–1.40) |
2.28 (1.10–4.73) |
0.09 |
1.20 (0.94–1.54) |
0.14 |
|
|
rs3138045 |
5,214 |
0.22 |
1.00 (0.82–1.22) |
1.25 (0.80–1.97) |
0.62 |
1.05 (0.89–1.23) |
0.56 |
|
|
rs2007960 |
--- |
0.39 |
1.03 (0.84–1.26) |
1.02 (0.78–1.34) |
0.96 |
1.01 (0.89–1.16) |
0.83 |
|
|
NFKBIB |
rs2053071 |
886 |
0.35 |
0.87 (0.71–1.06) |
1.08 (0.80–1.46) |
0.22 |
0.99 (0.86–1.13) |
0.86 |
|
rs12979755 |
3,098 |
0.39 |
0.99 (0.81–1.21) |
0.99 (0.75–1.31) |
0.99 |
0.99 (0.87–1.14) |
0.93 |
|
|
rs8108039 |
3,501 |
0.19 |
0.99 (0.81–1.21) |
1.40 (0.82–2.38) |
0.44 |
1.05 (0.89–1.24) |
0.57 |
|
|
rs3136642 |
233 |
0.39 |
1.03 (0.84–1.26) |
1.05 (0.80–1.39) |
0.93 |
1.03 (0.90–1.17) |
0.71 |
|
|
rs3136645 |
628 |
0.20 |
1.02 (0.83–1.24) |
1.23 (0.76–1.99) |
0.70 |
1.05 (0.89–1.24) |
0.56 |
|
|
rs3136646 |
--- |
0.22 |
0.99 (0.81–1.21) |
0.78 (0.51–1.18) |
0.49 |
0.94 (0.80–1.10) |
0.41 |
|
|
|
||||||||
|
Adjusted for race, age, area of residence, body mass index, hormone therapy use, oral contraceptive use, parity, and age at first birth; NFKBIA rs3138050 exclude Duke University participants; MAF, minor allele frequency among controls; bold = < 0.05; bp to next represents distance in base pairs between SNPs. |
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|
White et al. BMC Cancer 2009 9:170 doi:10.1186/1471-2407-9-170 |
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