The 180-gene GEPR to EGFR-targeted therapy stratifies a patient population demonstrating longer progression-free survival in metastatic CRC patients treated with cetuximab. The data from Khambata-Ford et al were classified using our predictive model and matched to PFS. The scatter plots (left) depict the individual data points and median PFS for each group. The Kaplan-Meier survival curves (right) depict PFS between the 'sensitive' (green) and 'resistant' (red) groups. A: KRAS-wildtype patients; B: all patients; and C: KRAS-mutant patients.
Balko and Black BMC Cancer 2009 9:145 doi:10.1186/1471-2407-9-145