BMC Cancer
Volume 8

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Carneiro A
Isinger A
Karlsson A
Johansson J
Jönsson G
Bendahl PO
Falkenback D
Halvarsson B
Nilbert M

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Carneiro A
Isinger A
Karlsson A
Johansson J
Jönsson G
Bendahl PO
Falkenback D
Halvarsson B
Nilbert M
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Research article

Prognostic Impact of Array-based Genomic Profiles in Esophageal Squamous Cell Cancer

Ana Carneiro¹^,2 , Anna Isinger¹ , Anna Karlsson¹ , Jan Johansson³ , Göran Jönsson¹ , Pär-Ola Bendahl¹ , Dan Falkenback⁴ , Britta Halvarsson⁵ and Mef Nilbert¹^,6

¹Department of Oncology, Lund University Hospital, 221 85 Lund, Sweden

²Department of Clinical Oncology, Portuguese Institute of Oncology, 1099-023 Lisbon, Portugal

³Department of Surgery, University Hospital, 221 85 Lund, Sweden

⁴Department of Surgery, Helsingborg Hospital, 251 87 Helsingborg, Sweden

⁵Department of Pathology, Helsingborg Hospital, 251 87 Helsingborg, Sweden

⁶Department of Clinical Sciences, Copenhagen University and Clinical Research Unit, Hvidovre Hospital, 2650 Hvidovre, Denmark

author email corresponding author email

BMC Cancer 2008, 8:98doi:10.1186/1471-2407-8-98


Published:	11 April 2008

Additional files

Additional file 1:

Clinicopathologic variables of tumors and survival of patients of the sample set. Table listing the clinicopathologic variables of tumors and survival of patients of the sample set analyzed in this study.

Format: XLS Size: 21KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 2:

Number of gains and losses by differentiation. Boxplot of the number of gained and lost clones according to tumor differentiation.

Format: TIFF Size: 15.9MB Download file

Additional file 3:

Number of gains and losses by tumor stage. Boxplot of the number of gained and lost clones according to tumor stage.

Format: TIFF Size: 16.2MB Download file

Additional file 4:

Copy number alterations, listed in decrescent prevalence order, in relation to tumor stage. Table listing the most frequent copy number alterations, sorted in decreasing order, in relation to tumor stage. Columns give the cytoband, start reporter, end reporter, size (Mbp), frequency of the change and candidate genes in the region.

Format: XLS Size: 29KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 5:

Chi2 test significant regions associated with positive lymph nodes (P < 0.05). Table listing the regions of aberrations that showed a significant statistical (P < 0.05) association with positive lymph nodes. Given are cytoband, start reporter, end reporter, size (Mbp) and the frequency across patients with positive lymph nodes and patients with negative lymph nodes. P-values were computed using Chi2 test.

Format: XLS Size: 24KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 6:

Chi2 test significant regions associated with metastasis at diagnosis (P < 0.05). Table listing the regions of aberrations that showed a significant statistical (P < 0.05) association with metastasis at diagnosis. Given are cytoband, start reporter, end reporter, size (Mbp) and the frequency across patients with metastasis at diagnosis and patients without metastasis at diagnosis. P-values were computed using Chi2 test.

Format: XLS Size: 21KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 7:

Regions correlated to prognosis identified by Cox analysis. Table listing the regions of aberrations significantly correlated (P < 0.05) to prognosis in univariate Cox analysis. Cytoband, start reporter, end reporter and size (Mbp) of the aberrant region are given.

Format: XLS Size: 22KB Download file

This file can be viewed with: Microsoft Excel Viewer