Table 2

Correlation of high MMP-13 expression with clinicopathological parameters and other biomarkers


High MMP-13 expression


Cancer Cells
 Stromal Fibroblasts


Parameters/Markers
 Total
 n
 %
 p
 n
 %
 p
Menopausal






     Pre-menopausal
 132
 64
 48.5
 0.949
 70
 53.0
 0.573
     Post-menopausal
 131
 63
 48.1
71
 56.5
Tumor Size






     <2 cm
 46
 25
 54.3
 0.365
 28
 60.9
 0.359
     >2 cm
 217
 102
 47.0
116
 53.5
Lymph Node Status






     N0
 128
 43
 33.6
 < 0.001
 55
 43
 < 0.001
     N1
 57
 25
 43.9
31
 54.4
     N2
 26
 17
 65.4
16
 61.5
     N3
 52
 42
 80.8
42
 80.8
Histological Grade
 68
 22
 32.35
 0.001
 27
 39.7
 0.071
     G1
 119
 56
 47.06
67
 56.3
     G2
 76
 49
 64.47
51
 54.8
     G3






ER Status
 101
 51
 50.5
 0.572
 56
 55.4
 0.859
     Negative
 162
 76
 46.9
88
 54.3
     Positive






PR Status
 101
 85
 52.5
 0.086
 95
 58.6
 0.109
     Negative
 162
 42
 41.6
49
 485
     Positive






HER2/neu Protein
 211
 94
 44.5
 0.0150
 101
 47.9
 < 0.001
     Negative
 52
 33
 63.5
43
 82.7
     Positive






MMP-2 Protein
 171
 81
 47.4
 0.234
 96
 56.1
 0.927
     Negative
 51
 29
 56.9
29
 56.9
     Positive






MMP-9 Protein
 162
 88
 54.3
 0.911
 81
 50.0
 0.367
     Negative
 58
 32
 55.2
42
 43.3
     Positive






TIMP-1 expression
 131
 50
 38.2
 < 0.001
 63
 48.8
 0.002
     Negative
 72
 52
 72.2
51
 70.8
     Positive






TIMP-2 Protein
 41
 15
 36.6
 0.080
 52
 35.6
 0.029
     Negative
 142
 74
 52.1
34
 51.5
     Positive






Zhang et al. BMC Cancer 2008 8:83   doi:10.1186/1471-2407-8-83