Figure 2.

Effect of alendronate treatment on the size and lymph node metastasis of orthotopic PC3 prostate tumors. Tumor size was measured using the formula: length × width × depth × π/6. The tumor volume was significantly smaller in alendronate treated mice compared with the control mice (A), p < 0.05, Student's t-test. According to the histomorphometrical analysis (B), the relative area of lymph node metastasis (%) was significantly smaller in alendronate-treated (n = 7) than in PBS-treated control animals (n = 7), p < 0.001, Student's t-test].