|
Mean values (CI) for QLQ-H&N35 scores before treatment (baseline) and follow-up and p-values and effect sizes for changes at follow-up compared to baseline |
||||||
| Base, n = 100 |
1 mo, n = 95 |
2 mo, n = 86 |
3 mo, n = 81 |
6 mo, n = 75 |
12 mo, n = 71 |
|
|
|
||||||
| EORTC QLQ-H&N35 |
||||||
| Scales* |
||||||
| Pain |
9.3 (6.4–12.2) |
28.5§ (23.9–33.0) |
17.0 (13.2–20.9) |
13.0 (9.2–16.7) |
12.3 (7.8–16.7) |
6.8 (3.2–10.4) |
| p†/ES‡ |
.000/0.99 |
.000/0.55 |
.016/0.28 |
ns/0.21 |
ns/0.08 |
|
| Swallowing |
6.8 (4.2–9.5) |
33.1§ (27.7–38.5) |
22.8§ (17.4–28.1) |
14.3 (9.1–19.6) |
11.3 (6.8–15.7) |
6.8 (3.3–10.3) |
| p†/ES‡ |
.000/0.96 |
.000/0.68 |
.000/0.39 |
.005/0.34 |
ns/0.15 |
|
| Senses |
5.2 (2.4–7.9) |
23.0§ (17.3–28.6) |
19.2§ (13.1–25.3) |
13.2 (8.6–17.8) |
9.6 (5.0–14.2) |
7.8 (3.6–11.9) |
| p†/ES‡ |
.000/0.70 |
.000/0.54 |
.000/0.49 |
.005/0.34 |
.010/0.31 |
|
| Speech |
37.2 (32.5–41.9) |
44.9 (39.5–50.4) |
34.4 (28.3–40.6) |
24.6§ (19.0–30.1) |
24.3§ (18.3–30.3) |
16.0§ (11.8–20.2) |
| p†/ES‡ |
.013/0.25 |
ns/0.09 |
.001/0.40 |
.001/0.45 |
.000/0.84 |
|
| Social eating |
7.1 (4.1–10.0) |
29.1§ (23.3–34.9) |
17.4§ (12.6–22.3) |
11.0 (6.3–15.7) |
7.3 (3.3–11.4) |
6.0 (2.1–9.9) |
| p†/ES‡ |
.000/0.75 |
.000/0.50 |
.014/0.28 |
ns/0.17 |
ns/0.09 |
|
| Social contact |
6.9 (4.5–9.3) |
9.4 (6.6–12.1) |
7.6 (5.2–10.1) |
5.2 (2.4–8.1) |
4.5 (1.4–7.5) |
2.8 (0.3–5.3) |
| p†/ES‡ |
.049/0.18 |
ns/0.10 |
ns/0.05 |
ns/0.16 |
.003/0.36 |
|
| Sexuality |
33.0 (25.4–40.6) |
36.6 (28.9–44.3) |
37.2 (28.9–45.5) |
34.9 (27.1–46.6) |
27.1 (19.4–34.9) |
27.0 (19.2–34.7) |
| p†/ES‡ |
ns/0.12 |
ns/0.12 |
ns/0.17 |
ns/0.05 |
ns/0.01 |
|
| Single items* |
||||||
| Dry mouth |
22.7 (16.7–28.7) |
39.30§ (32.5–46.1) |
34.1§ (27.1–41.1) |
34.6§ (27.3–41.9) |
34.7§ (27.3–42.1) |
30.1 (23.4–36.7) |
| p†/ES‡ |
.000/0.52 |
.000/0.44 |
.000/0.53 |
.000/0.54 |
.002/0.40 |
|
| Sticky saliva |
20.2 (14.8–25.6) |
50.7§ (43.7–57.7) |
45.0§ (37.4–52.5) |
37.1§ (29.9–44.3) |
38.7§ (30.9–46.4) |
31.9§ (25.1–38.7) |
| p†/ES‡ |
.000/0.91 |
.000/0.80 |
.000/0.68 |
.000/0.66 |
.000/0.55 |
|
| Coughing |
29.0 (24.0–34.0) |
48.1§ (42.0–54.2) |
40.3§ (33.5–47.1) |
35.4 (29.2–41.6) |
32.4 (25.0–39.9) |
24.9 (18.8–31.0) |
| p†/ES‡ |
.000/0.63 |
.004/0.33 |
.026/0.26 |
ns/0.21 |
ns/0.02 |
|
| Felt ill |
17.0 (12.4–21.6) |
28.4§ (22.4–34.4) |
19.0 (13.7–24.3) |
16.1 (11.1–21.1) |
10.2 (6.2–14.2) |
8.5 (4.5–12.4) |
| p†/ES‡ |
.000/0.0.45 |
ns/0.17 |
ns/0.08 |
ns/0.20 |
.034/0.26 |
|
|
*Min-max: 0–100 § Indicates clinical significant change measured from baseline, i.e. a change of >10 points. †p-value significant at ≤ 0.05, ns = not significant. ‡Effect size (ES) of change was calculated as mean change from baseline, divided by the standard deviation of change. Criteria: trivial 0 to < 0.20; small 0.20 to < 0.50; moderate 0.50 to < 0.80; and large ≥ 0.80 | ||||||
Johansson et al. BMC Cancer 2008 8:80 doi:10.1186/1471-2407-8-80 |
||||||