Table 1

List of the 60 selected genes

Gene symbols

Alternate symbols

Gene name

Chromosome location

Genbank accession number


NFKB genes (n = 11)

NFKB1

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)

4q24

NM_003998

NFKB2

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

10q24

NM_002502

REL

v-rel reticuloendotheliosis viral oncogene homolog

2p13-p12

NM_002908

RELA

NFKB3

v-rel reticuloendotheliosis viral oncogene homolog A (p65)

11q13

NM_021975

RELB

v-rel reticuloendotheliosis viral oncogene homolog B

19q13.32

NM_006509

CHUK

IKBKA

Conserved helix-loop-helix ubiquitous kinase

10q24-q25

NM_001278

IKBKB

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

8p11.2

NM_001556

IKBKG

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

Xq28

NM_003639

NLK

Nemo like kinase

17q11.2

NM_016231

NFKBIA

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

14q13

NM_020529

NFKBIB

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

19q13.1

NM_1001716

Apoptosis (n = 12)

BCL2A1

BFL1/A1

Baculoviral IAP repeat-containing 2

15q24.3

NM_004049

GADD45B

Growth arrest and DNA-damage-inducible, beta

19p13.3

NM_015675

TNFRSF10B

TRAILR2, DR5

Tumor necrosis factor receptor superfamily, member 10b

8p22-p21

NM_003842

FASLG

FASL, TNFSF6

Fas ligand (TNF superfamily, member 6)

1q23

NM_000639

BIRC4

XIAP

Baculoviral IAP repeat-containing 4

Xq25

NM_001167

TNFAIP3

A20

Tumor necrosis factor, alpha-induced protein 3

6q23

NM_006290

TRAF2

TNF receptor-associated factor 2

9q34

NM_021138

IER3S

Immediate early response 3, large transcript

6p21.3

NM_003897

IER3L

Immediate early response 3, short transcript

6p21.3

NM_052815

BIRC2

c-IAP1

Baculoviral IAP repeat-containing 2

11q22

NM_001166

MCL1S

Myeloid cell leukemia sequence 1 (BCL2-related), short transcript

1q21

NM_182763

MCL1L

Myeloid cell leukemia sequence 1 (BCL2-related), large transcript

1q21

NM_021960

Immune response (n = 15)

IL1A

Interleukin 1, alpha

2q14

NM_000575

IL1B

Interleukin 1, beta

2q14

NM_000576

IL6

Interleukin 6 (interferon, beta 2)

7p21

NM_000600

IL12B

Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

5q31.1-q33.1

NM_002187

IL15

Interleukin 15

4q31

NM_000585

CCL2

MCP-1

Chemokine (C-C motif) ligand 2

17q11.2-q21.1

NM_002982

CCR5

Chemokine (C-C motif) receptor 5

3p21

NM_000579

TNFRSF11A

RANK

Tumor necrosis factor receptor superfamily, member 11a, activator of NFKB

18q22.1

NM_003839

TNFSF11

RANKL

Tumor necrosis factor (ligand) superfamily, member 11

13q14

NM_003701

TNF

Tumor necrosis factor (TNF superfamily, member 2)

6p21.3

NM_000594

IRF7

Interferon regulatory factor 7

11p15.5

NM_001572

GBP1

Guanylate binding protein 1, interferon-inducible, 67kDa

1p22.2

NM_002053

CD40

CD40 antigen (TNF receptor superfamily member 5)

20q12-q13.1

NM_001250

CD40LG

CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome)

Xq26

NM_000074

CD48

CD48 molecule

1q21.3-q22

NM_001778

Cell Proliferation (n = 8)

CSF1

Colony stimulating factor 1 (macrophage)

1p21-p13

NM_000757

CSF1R

Colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog

5q33-q35

NM_005211

CSF2

Colony stimulating factor 2 (granulocyte-macrophage)

5q31.1

NM_000758

CCND1

Cyclin D1 (PRAD1: parathyroid adenomatosis 1)

11q13

NM_053056

CCND2

Cyclin D2

12p13

NM_001759

CCND3

Cyclin D3

6p21.3

NM_001760

CCNG1

Cyclin G1

5q32-q34

NM_004060

SOD2

Mn-SOD

Superoxide dismutase 2, mitochondrial

6q25.3

NM_000636

Tumor progression (n = 10)

MMP9

Matrix metalloproteinase 9 (gelatinase B, 92 kDa type IV collagenase)

20q11.2-q13.1

NM_004994

MMP11

Matrix metalloproteinase 11 (stromelysin 3)

22q11.23

NM_005931

PLAU

UPA

Plasminogen activator, urokinase

10q24

NM_002658

CTSB

Cathepsin B

8p22

NM_001908

CXCR4

Chemokine (C-X-C motif) receptor 4

2q21

NM_003467

CXCL12

SDF1

Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)

10q11.1

NM_000609

ICAM1

Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor

19p13.3-p13.2

NM_000201

VCAM1

Vascular cell adhesion molecule 1

1p32-p31

NM_001078

SELE

ELAM1

Selectin E (endothelial adhesion molecule 1)

1q22-q25

NM_000450

TNC

HXB

Tenascin C (hexabrachion)

9q33

NM_002160

Angiogenesis (n = 4)

IL8

Interleukin 8

4q13-q21

NM_000584

CXCL1

GRO1

Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

4q21

NM_001511

VEGF

VEGFA

Vascular endothelial growth factor

6p12

NM_003376

PTGS2

COX2

Prostaglandin-endoperoxide synthetase 2

1q25.2-q25.3

NM_000963


Lerebours et al. BMC Cancer 2008 8:41   doi:10.1186/1471-2407-8-41

Open Data