Table 2

Sensitivity and specificity of the templates used for the detection of MRD in children with ALL

*Cell surface antigen

1Sensitivity (%)

2Specificity (%)

3Detection level of MRD


OAcSGP

100

100

Till 5%

CD19

84.27

100

CD10

58.43

100

CD34

25.8

100

CD3

15.7

100

CD7

15.7

100

OAcSGP, CD19

84.27

100

Till 0.1%

OAcSGP, CD10

58.43

100

OAcSGP, CD34

25.8

100

OAcSGP, CD3

15.7

100

OAcSGP, CD7

15.7

100

CD19, CD10

58.43

100

CD19, CD34

25.8

100

CD3, CD7

15.7

100

OAcSGP, CD10, CD19

58.43

100

Till 0.01%

OAcSGP, CD34, CD19

25.8

100

OAcSGP, CD7, CD3

15.7

100


* Single or a combination (double or triple colour) of cell surface antigen/s used for the MRD assay

1 Probability of a positive test among patients with disease

2 Probability of a negative test among patients without disease

3 Detection level of the presence of diseased cells in the patient

Chowdhury et al. BMC Cancer 2008 8:40   doi:10.1186/1471-2407-8-40

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