Failure of early clearance of lymphoblasts, during induction 1 of treatment, in R3 region is a poor prognosis increasing the possibility of relapse. The status of OAcSGP+CD10+CD19+, at diagnosis, in PBB-ALL (a) and BMB-ALL (d) of a representative profile of a patient is shown. After the fifth week of chemotherapy, the MRD of this patient in PB is high (b) as compared to that of another B-ALL patient (h) who is in CR. Similarly the high MRD of this patient in BM (after 5 weeks of treatment) is shown (e). The MRD in PB and BM at the time of relapse is shown in (c) and (f) respectively while that of a patient having CR throughout the treatment is shown in (i).
Chowdhury et al. BMC Cancer 2008 8:40 doi:10.1186/1471-2407-8-40