Table 3 |
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|
Personal, clinical and tumoral phenotypic characteristics comparison from both BC and MM pathologies in the four SNPs tested |
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|
Tumour |
rs4516035 |
rs2228570 |
rs731236 |
rs739837 |
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|
Type |
Characteristic |
OR* (95% CI) |
p-value |
OR* (95% CI) |
p-value |
OR* (95% CI) |
p-value |
OR* (95% CI) |
p-value |
|
|
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|
BREAST CANCER |
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|
|
|||||||||
|
Metastasis‡ |
0.53 (0.25–1.11) |
0.09 |
1.00 (0.51–1.96) |
0.99 |
1.20 (0.63–2.27) |
0.58 |
1.11 (0.57–2.17) |
0.75 |
|
|
Tumor histology (Invasive)‡ |
0.87 (0.57–1.32) |
0.51 |
0.83 (0.54–1.28) |
0.40 |
1.10 (0.72–1.69) |
0.66 |
0.75 (0.49–1.15) |
0.19 |
|
|
Tumor grade (Grade > 1)‡ |
0.93 (0.67–1.30) |
0.68 |
1.19 (0.84–1.68) |
0.33 |
1.22 (0.87–1.70) |
0.26 |
0.76 (0.54–1.05) |
0.09 |
|
|
Tumor size (> 2 cm)‡ |
1.02 (0.77–1.35) |
0.92 |
0.98 (0.73–1.30) |
0.88 |
1.14 (0.86–1.51) |
0.37 |
0.81 (0.61–1.08) |
0.15 |
|
|
Nodal involvement‡ |
0.93 (0.70–1.23) |
0.61 |
0.95 (0.71–1.27) |
0.72 |
0.94 (0.71–1.25) |
0.69 |
1.09 (0.82–1.45) |
0.54 |
|
|
ER positive‡ |
0.96 (0.66–1.41) |
0.85 |
1.24 (0.84–1.84) |
0.28 |
1.31 (0.90–1.90) |
0.16 |
1.02 (0.71–1.46) |
0.91 |
|
|
PR positive‡ |
0.92 (0.67–1.26) |
0.60 |
1.12 (0.80–1.55) |
0.51 |
0.91 (0.67–1.24) |
0.56 |
1.12 (0.83–1.51) |
0.48 |
|
|
|
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|
MELANOMA |
|||||||||
|
|
|||||||||
|
Light Eye Colour+ |
1.03 (0.79–1.34) |
0.82 |
0.91 (0.69–1.21) |
0.52 |
0.92 (0.70–1.21) |
0.56 |
1.06 (0.81–1.39) |
0.64 |
|
|
Blond/Red Hair Colour+ |
0.99 (0.71–1.40) |
0.99 |
0.78 (0.55–1.13) |
0.19 |
1.02 (0.73–1.44) |
0.89 |
1.45 (0.89–1.74) |
0.20 |
|
|
Fair Skin Colour+ |
0.97 (0.75–1.26) |
0.83 |
1.08 (0.82–1.42) |
0.57 |
0.86 (0.66–1.12) |
0.25 |
1.31 (1.00–1.70) |
0.048 |
|
|
N° of Nevi = 50+ |
0.97 (0.66–1.40) |
0.85 |
1.00 (0.67–1.49) |
0.99 |
1.06 (0.72–1.54) |
0.77 |
1.34 (0.90–1.97) |
0.15 |
|
|
Presence of Lentigines+ |
1.03 (0.79–1.34) |
0.84 |
0.79 (0.59–1.05) |
0.11 |
1.20 (0.91–1.58) |
0.21 |
0.90 (0.69–1.18) |
0.45 |
|
|
Presence of Childhood Sunburns+ |
1.12 (0.87–1.45) |
0.39 |
0.65 (0.49–0.86) |
0.003 |
1.10 (0.84–1.43) |
0.49 |
0.91 (0.70–1.19) |
0.50 |
|
|
Other MM‡ |
1.26 (0.52–3.03) |
0.61 |
2.43 (0.95–6.19) |
0.060 |
1.83 (0.73–4.56) |
0.19 |
0.70 (0.26–1.85) |
0.47 |
|
|
Fitzpatrick's photoype I/II‡ |
0.74 (0.51–1.09) |
0.13 |
0.85 (0.63–1.46) |
0.89 |
0.91 (0.62–1.34) |
0.63 |
1.43 (0.97–2.12) |
0.070 |
|
|
Tumor Location (Head/Neck/Trunk)‡ |
1.54 (1.08–2.20) |
0.020 |
1.16 (0.79–1.72) |
0.45 |
1.16 (0.81–1.65) |
0.42 |
1.17 (0.82–1.67) |
0.38 |
|
|
Breslow Index (T2/T3/T4)‡ |
1.04 (0.72–1.51) |
0.82 |
1.20 (0.80–1.79) |
0.38 |
0.84 (0.57–1.24) |
0.38 |
1.01 (0.69–1.47) |
0.96 |
|
|
|
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|
*OR: Odds Ratio per minor allele; CI: Confidence Interval, unadjusted p-values. +Cases and controls pooled for each variable. ‡Cases only considered. Statistically significant results (p < 0.05) indicated in bold. |
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|
Barroso et al. BMC Cancer 2008 8:385 doi:10.1186/1471-2407-8-385 |
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