Table 6

Dose-response data for smokeless tobacco and pancreatic cancer

Studya

Smoking

Sex

ST use

RR/OR



Type

Exposure

Cases

Estimate

(95% CI)



Swedish Construction Workers [11]

Never

M

Snuff

Never

63

1.00 (reference)


1–9 g/day

6

1.90 (0.80–4.30)


10+ g/day

13

2.10 (1.10–3.80)


Third National Cancer Survey [16]

Any

M

STb

Never

88

1.00 (reference)


Lowc

2

0.31 (0.08–1.27)d


Highc

1

0.25 (0.04–1.89)d


Texas [15]

Anye

M+F

Chewing

Never

774

1.00 (reference)


Low/moderatef

22

0.60 (0.30–1.20)


High

12

0.60 (0.30–1.20)


Snuff

Never

790

1.00 (reference)


Low/moderatef

9

0.60 (0.20–1.50)


Highg

9

0.60 (0.20–1.30)


a Fuller details of the studies are given in Tables 1 and 2

b Chewing or snuff

c The exposed population was divided into approximately equal numbers by the product of consumption x years of use

d CI were estimated from data provided

e The source also provides results for ever cigarette smokers – chewing 1.00, 0.70 (0.40–1.40), 0.50 (0.20–1.50), snuff 1.00, 0.80 (0.30–2.10), 0.50 (0.20–1.50), and also for never cigarette smokers – chewing 1.00, 0.60 (0.20–2.30), 0.60 (0.20–1.70), and snuff 1.00, 0.00, 0.60 (0.20–2.10)

f Low or moderate intake: ≤ 20 time-years (times/day x years of use)

g High intake: > 20 time-years

Sponsiello-Wang et al. BMC Cancer 2008 8:356   doi:10.1186/1471-2407-8-356

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