Table 2

Univariate and multivariate Cox proportional analyses of distant-metastasis-free survival

Univariate analysis

Multivariate analysis



Study

Variable

Hazard ratio

(95% CI)

p-value

Hazard ratio

(95% CI)

p-value


Training set

(untreated set)

14-gene signature

4.34 (1.86–10.1)

0.001

3.16 (1.27–7.87)

0.014

Age

1.00 (0.97–1.03)

0.853

1.00 (0.97–1.03)

0.956

Tumor size

1.91 (1.00–3.63)

0.050

1.41 (0.68–2.91)

0.353

Grade 2

2.21 (1.05–4.70)

0.038

1.45 (0.65–3.22)

0.360

Grade 3

1.72 (0.22–13.3)

0.604

0.72 (0.09–6.00)

0.759


Validation set

(untreated set)

14-gene signature

4.71 (2.33–9.51)

<0.0001

4.02 (1.91–8.44)

0.0002

Age

1.03 (1.00–1.05)

0.024

1.02 (0.99–1.04)

0.193

Tumor size

1.75 (1.25–2.46)

0.001

1.37 (0.95–2.00)

0.092

Grade 2

2.43 (1.10–5.40)

0.029

1.25 (0.55–2.87)

0.592

Grade 3

3.01 (1.23–7.39)

0.016

1.11 (0.43–2.87)

0.833


Tam-treated set

14-gene signature

3.61 (0.86–15.1)

0.079

3.50 (0.58–21.2)

0.172

Age

1.04 (0.98–1.10)

0.241

1.06 (0.98–1.14)

0.166

Tumor grade

1.50 (0.50–4.49)

0.468

NA

NA


Tutt et al. BMC Cancer 2008 8:339   doi:10.1186/1471-2407-8-339

Open Data