Additional file 4.

mRNA Enhancement. The RNAs used to profile the genes in the training set were enriched whereas the RNAs in the validation and tamoxifen treatment sets were used directly. To ensure that the profiling methods produced similar results, we compared the enriched and unenriched expression profile of 14 genes in 50 training set samples. Good correlation (R2 = 0.9931) of gene expression levels was observed between the metastasis scores generated with the enriched vs. unenriched samples. Perfect agreement was obtained on risk category calls.

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Tutt et al. BMC Cancer 2008 8:339   doi:10.1186/1471-2407-8-339