Additional file 11.

Ingenuity pathway analysis of prognostic 14-gene signature. The primary network identified below indicates the majority of the 14 genes of the signature are associated with known important tumor suppressors (TP53 and CDKN2A) and cell cycle control (CDC2). Nodes are displayed using various shapes that represent the functional class of the gene product (diamond-enzymes, ovals-transcription factors, triangles-kinase, circles-others). A solid line indicates a direct interaction while a dashed line indicates an indirect interaction. A line without an arrowhead indicates binding. Genes from 14-gene signature are highlighted in grey. Note that thirteen out of 14 genes of the signature are in the network.

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Tutt et al. BMC Cancer 2008 8:339   doi:10.1186/1471-2407-8-339