Figure 4.

Heatmaps of expression changes of selected genes associated with apoptotic pathways after incubation with doxorubicin for 24 h ordered by responder group (5 a,b), grading (6 a,b), and histologic subtype (7 a/b). Expression changes as determined by comparison analysis were considered only if the probeset showed at least one P detection in untreated/treated sample pairs. Excluded expression changes are shown in grey. Only probesets with expression changes in 7 or more samples are given. Horizontal rows represent individual probesets. Vertical columns represent individual samples (left to right: low responders to high responders); gene symbols are indicated to the right. Gene expression changes are indicated by a continuous scale; the brightest red indicating ≥ 4-fold up-regulation; and, brightest green ≥ 4-fold down-regulated gene expression relative to the untreated control sample.