Additional File 1.

Clinical and hematological features of the studied CMMLs. This table provides details on disease and patients. CMMLs are classified by a double line according to antecedents. Samples 3 and 37 are from the same patient. CMML: chronic myelomonocytic leukemia. In bold: myeloproliferative CMML and corresponding WBC. AT-CMML(AML-M4): acute transformation of CMML in acute myeloid leukemia of M4 FAB type. MDS: myelodysplasic syndromes. RARS: refractory anemia with ring sideroblasts. EPO: erythropoïetin. WBC: white blood cell count. TA: therapeutic abstention. DGP: dysgranulopoiesis, DMK: dysmegakaryocytopoiesis, DEP: dyserythropoiesis. 2, 95, 75: hematological malignancies were concomitant of the diagnosis of CMML. 8*: thrombopenia with a diagnosis of MDS (not done in our Institute). Apparition of anemia 2 weeks before the sampling and then treated with EPO. Variable monocytosis around 1.2 G/L but unlikely below 1 G/L at the time of sampling. 25*: persistant and stable monocytosis since June 2006 (1.2 G/L) but unlikely below 1 G/L at the time of sampling. 63*: mild anemia and thrombopenia with a diagnosis of MDS (not done in our Institute) and then under surveillance. 74*: treated for AML (not in our Institute) in 1992 (chemotherapy) and relapse (AML-M5) in our Institute in 2005 (chemotherapy). The cytological aspect of the bone marrow in January 2007 was CMML type 2. 34*: because of the important bone marrow dysplasia and the imprtant cellularity the diagnosis of a acute phase of CMML was made. 80*: antecedent of monocytosis non explored. 88*: thrombopenia since 2005 and diagnosis of CMML (2006) made out of our Institute. 106*: stable monocytosis since February 2000. One sister with breast cancer. One brother with head and neck cancer and her mother with colon cancer (deceased).

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Gelsi-Boyer et al. BMC Cancer 2008 8:299   doi:10.1186/1471-2407-8-299