|
CHEK2 1217G>A Frequency |
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| Group |
BRCA |
CTRL |
P-Value |
|
|
|||
| 1 |
4.00% (1/25)* |
0.00% (0/25)* |
1.00 |
| 2 |
0.81% (1/124)* |
0.00% (0/116)* |
1.00 |
| 3 |
0.18% (1/543) |
N/A |
N/A |
| 4 |
N/A |
0.34% (22/6432) |
N/A |
|
|
|||
| Total |
0.43% (3/692) |
0.33% (22/6573) |
0.73 |
|
*Genotyped for 1100delC which was observed in 2.01% (3/149) of cases vs 0.7% (1/141) controls. If we compare the frequency in cases with that seen in the same neonatal controls used in this study, that were also tested for 1100delC by Zhang et al [30] (19 1100delC carriers among 6460 controls), then the difference between cases and controls is statistically significant (P = 0.01). | |||
Novak et al. BMC Cancer 2008 8:239 doi:10.1186/1471-2407-8-239 |
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