Table 4

Median GDMI stratified by different histopathologic characteristics for normal disease, tumor, and their ratios.
Characteristics
 Enzymes
 Normal Disease
 p-value
 Tumor
 p-value
 Tumor/Normal Disease
 p-value






(Median)
(Median)
(Median)
Stage
Stage IA
(n = 10)
 Stage IB
(n = 7)
Stage IA
(n = 10)
 Stage IB
(n = 7)
Stage IA
(n = 10)
 Stage IB
(n = 7)

HinP1I
 0.20
 0.15
 0.22
 0.18
 0.26
 0.005**
 0.92
 1.74
 0.006**

HypCH4IV
 0.37
 0.37
 0.92
 0.39
 0.43
 0.59
 1.05
 1.33
 0.08*

HpaII
 0.31
 0.32
 0.49
 0.35
 0.44
 0.13
 1.20
 1.32
 0.19
Grade of Differentiation
Well Diff
(n = 3)
 Nonwell Diff
(n = 15)
Well Diff
(n = 3)
 Nonwell Diff
(n = 15)
Well Diff
(n = 3)
 Nonwell Diff
(n = 15)

HinP1I
 0.20
 0.20
 0.31
 0.19
 0.25
 0.17
 1.11
 1.21
 0.86

HypCH4IV
 0.37
 0.37
 0.77
 0.29
 0.44
 0.10*
 0.79
 1.14
 0.04**

HpaII
 0.31
 0.32
 0.68
 0.28
 0.41
 0.01**
 0.82
 1.33
 0.01**
Tumor Size
T1
(n = 10)
 T2
(n = 8)
T1
(n = 10)
 T2
(n = 8)
T1
(n = 10)
 T2
(n = 8)

HinP1I
 0.20
 0.16
 0.66
 0.18
 0.25
 0.04**
 0.99
 1.47
 0.04**

HypCH4IV
 0.37
 0.35
 0.59
 0.39
 0.42
 0.70
 1.01
 1.15
 0.12

HpaII
 0.32
 0.32
 0.62
 0.32
 0.43
 0.08*
 1.14
 1.31
 0.17

Numbers in bold with asterisks indicate statistical significance of non-parametric Wilcoxon/Kruskal-Wallis tests with a threshold of p <= 0.05 (**) or p <= 0.10 (*).

Anisowicz et al. BMC Cancer 2008 8:222   doi:10.1186/1471-2407-8-222