|
Analysis of the effect of MMP-2 siRNA or TIMP-2 overexpression on ameloblastoma cell invasion. |
||
| Group |
Invaded cells (Cells/Well) |
Inhibition rate of invasion |
|
|
||
| MMP-2siRNA |
||
| Mock |
137 ± 21 |
0 |
| Lipofectamine |
129 ± 18 |
5.8 |
| pRNA-neg |
131 ± 28 |
4.4 |
| pRNA-MMP-2(1 μg) |
116 ± 24* |
15.3 |
| pRNA-MMP-2(2 μg) |
61 ± 16* |
55.5 |
| pRNA-MMP-2(3 μg) |
53 ± 20* |
61.3 |
| TIMP-2 overexpression |
||
| Mock |
128 ± 18 |
0 |
| Lipofectamine |
123 ± 21 |
3.9 |
| pcDNA-neg |
117 ± 16 |
8.6 |
| pcDNA-TIMP-2(1 μg) |
97 ± 25* |
24.2 |
| pcDNA-TIMP-2(2 μg) |
59.8 ± 23* |
53.3 |
| pcDNA-TIMP-2(3 μg) |
63.4 ± 19* |
50.5 |
|
*Compared with the mock, lipifectamine or vector controls, respectively, P < 0.05. | ||
Wang et al. BMC Cancer 2008 8:182 doi:10.1186/1471-2407-8-182 |
||