Table 1

Analysis of the effect of MMP-2 siRNA or TIMP-2 overexpression on ameloblastoma cell invasion.

Group

Invaded cells (Cells/Well)

Inhibition rate of invasion

MMP-2siRNA

Mock

137 ± 21

0

Lipofectamine

129 ± 18

5.8

pRNA-neg

131 ± 28

4.4

pRNA-MMP-2(1 μg)

116 ± 24*

15.3

pRNA-MMP-2(2 μg)

61 ± 16*

55.5

pRNA-MMP-2(3 μg)

53 ± 20*

61.3

TIMP-2 overexpression

Mock

128 ± 18

0

Lipofectamine

123 ± 21

3.9

pcDNA-neg

117 ± 16

8.6

pcDNA-TIMP-2(1 μg)

97 ± 25*

24.2

pcDNA-TIMP-2(2 μg)

59.8 ± 23*

53.3

pcDNA-TIMP-2(3 μg)

63.4 ± 19*

50.5

*Compared with the mock, lipifectamine or vector controls, respectively, P < 0.05.

Wang et al. BMC Cancer 2008 8:182   doi:10.1186/1471-2407-8-182