Summary of BRCA1 abnormalities and associated features: Pathology refers to the tumor histopathology. Serous or Ser = serous carcinoma; Undiff = undifferentiated carcinoma; HG = high-grade; LG = low-grade; Clear cell = clear cell carcinoma; Endo = endometrioid carcinoma; G1 = grade 1; G2 = grade 2; G3 = grade 3. BRCA1 Status: Mut = mutation; G = germline; S = somatic; N = no mutations. LOH = loss of heterozygosity where LOH indicates that loss of heterozygosity is present, NO indicates that loss of heterozygosity is not present, and MSI indicates that microsatellite instability is present in the tumor. Meth refers to BRCA1 promoter hypermethylation. Tumors containing ≥ 4% fully methylated molecules are designated as methylated (M) and are highlighted in orange, whereas tumors containing < 4% are designated as unmethylated (U). RNA refers to relative RNA expression compared to the average RNA expression in all samples, where the average RNA expression = 1.0. Tumors with relative RNA expression <0.7 are highlighted in aqua as showing BRCA1/BRCA2 loss. IHC refers to BRCA1 immunohistochemistry; (+) indicates tumors with > 1% of nuclei stained positive for BRCA1, (-) indicates tumors with <1% of nuclei positive. N/A indicates that the data is not available for technical reasons.
Press et al. BMC Cancer 2008 8:17 doi:10.1186/1471-2407-8-17