Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides

doi:10.1186/1471-2407-8-122

BMC Cancer
Volume 8

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Otto C
Kaemmerer U
Illert B
Muehling B
Pfetzer N
Wittig R
Voelker HU
Thiede A
Coy JF

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Otto C
Kaemmerer U
Illert B
Muehling B
Pfetzer N
Wittig R
Voelker HU
Thiede A
Coy JF
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Research article

Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides

Christoph Otto^*¹ , Ulrike Kaemmerer^*² , Bertram Illert³ , Bettina Muehling¹ , Nadja Pfetzer² , Rainer Wittig⁴ , Hans Ullrich Voelker⁵ , Arnulf Thiede³ and Johannes F Coy⁴

¹Experimental Transplantation Immunology, Department of Surgery, University of Würzburg Hospital, Oberdürrbacher Str. 6, D-97080 Würzburg, Germany

²Department of Obstetrics and Gynaecology, University of Würzburg Hospital, Josef-Schneider-Str. 4, D-97080 Würzburg, Germany

³Department of Surgery, University of Würzburg Hospital, Oberdürrbacher Str. 6, D-97080 Würzburg, Germany

⁴Tavartis GmbH, Kroetengasse 10, D-64853 Otzberg, Germany

⁵Institute of Pathology, University of Würzburg, Josef-Schneider-Str. 2, D-97080 Würzburg, Germany

author email corresponding author email* Contributed equally

BMC Cancer 2008, 8:122doi:10.1186/1471-2407-8-122


Published:	30 April 2008

Additional files

Additional file 1:

Immunohistochemical analysis of representative tumours of the KD (animal 9) and SD (animal 16) groups. The carcinoma cells (pan cytokeratin-positive) located within the viable zone around the necrosis have proliferated (Ki-67 antigen-positive) and exhibit a glycolytic phenotype (TKTL1-positive). The expression of Glut-1 correlated with the strong glucose uptake and lactate production shown in Fig. 1 (Magnification: ×250).

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Additional file 2:

Influence of the ketogenic diet on vascularity in tumours of the human gastric adenocarcinoma cell line 23132/87. Representative tumour sections from the KD (animal 11) and SD (animal 13) groups are shown. Vessels were stained with the rat anti-mouse CD34 antibody RAM34 as described in Methods (Magnification: ×400).

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